Peripheral Vasodilation in Obese Humans
Summary
The growing population of obese adults is predicted to create a large public health burden in the next few decades. This study examines function of small blood vessels providing blood flow to skeletal muscles, to test if younger obese individuals (≤40 years old, BMI \>30) are already displaying reductions in blood vessel function. This study will test if the signals blood vessels use to increase blood flow are changing in these same subjects. Findings from this study may help create treatments to delay or prevent some of the negative effects of obesity on vascular health.
Timeline
- Start
- 2012-04-16
- Primary completion
- 2021-11
- Completion
- 2021-11
Outcome
Outcome not reported
Stopped (Enrollment): “Due to COVID-19, difficulty obtaining study drugs, difficulty recruiting obese subjects, and limited access to on-call physicians.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetylcholine | Small molecule | — | Other |
| Subject | BARIUM SULFATE | Small molecule | — | Other |
| Subject | Bradykinin | Protein / enzyme biologic | — | Other |
| Subject | Isoproterenol | Small molecule | — | — |
| Subject | Ketorolac | Other / unclassified | — | Other |
| Subject | L-N-monomethyl Arginine Acetate | Unknown | — | Other |
| Subject | adenosine triphosphate | Small molecule | — | Other |