drugset
Drugs / Tyramine
last change Oct 2025 re-read 2 minutes ago

Tyramine

also known as 2-p-hydroxyphenylethylamine · FEMA NO. 4215 · NSC-249188 · Ractopamine hydrochloride suspension impurity, tyramine- · Systogene · Tocosine · TYRAMINE HYDROCHLORIDE · Tyrosamine · +1 more

Small molecule

Developed for
chemotherapy-induced alopecia
Investigated by
Boehringer Ingelheim · Celgene Corporation

Trials 2 · a red edge is where a trial was stopped

today NCT03979820 · Ph 1 NCT03694119 · Ph 1
20192020202120222023202420252026
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 1 NCT03979820 Jul 2019 → Apr 2020 — Boehringer Ingelheim Terminated No outcome recorded
Phase 1 NCT03694119 Jul 2018 → Jan 2019 — Celgene Corporation Completed No outcome recorded
Also used as a comparator or background therapy in 3 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT01539473 Background Feb → May 2012 — Merck & Co., Inc. Completed No outcome recorded
Phase 1 NCT00748059 Background Dec 1996 → Dec 2020 autonomic nervous system disorder, disorder of catecholamine synthesis, orthostatic hypotension Vanderbilt University Medical Center Completed No outcome recorded
Phase 31 trial
Phase 3 NCT06762548 Comparator Oct 2025 → Sep 2026 expected chemotherapy-induced alopecia, chemotherapy-induced toxicity Applied Biology, Inc. Not yet recruiting No outcome recorded

Evidence & citations 13 cited values

Every value below carries the sentence it was read from. 7 sources stand behind the page.

FieldValueCited text
Known as Tyramine “Topical α1 agonist combination of Phenylephrine + Tyramine + Synephrine” NCT06762548 ↗
4

NCT03694119 ↗

NCT01539473 ↗

NCT00748059 ↗

NCT03979820 ↗
Known as 2-p-hydroxyphenylethylamine ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as FEMA NO. 4215 ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as NSC-249188 ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as Ractopamine hydrochloride suspension impurity, tyramine- ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as Systogene ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as Tocosine ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as TYRAMINE HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as Tyrosamine ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Known as Uteramine ChEMBL registry synonym — accepted as the source's own label CHEMBL11608 ↗
Action Activate “Topical α1 agonist combination of Phenylephrine + Tyramine + Synephrine” NCT06762548 ↗
Modality Small molecule — CHEMBL11608 ↗
Route Oral “coadministered oral tyramine” PMID 23612197 ↗ Apr 2013