Improving Treatment Outcomes for Prescription Opioid Dependence
Summary
Overall, this proposal seeks to improve treatment strategies for the significant public health problem of prescription opioid dependence by determining whether gabapentin, a non-narcotic pharmaceutical agent with minimal abuse potential and preliminary efficacy, will be effective in ameliorating withdrawal symptoms, craving and illicit drug use in prescription opioid dependent participants undergoing a 10-day detoxification from buprenorphine. In addition, the acceptability and feasibility of transitioning to depot naltrexone therapy will also be determined. If successful, this study would provide data to support further development of gabapentin as a pharmacological tool for improved outcomes during opioid detoxification as well as an integrated outpatient approach for treating prescription opioid dependence.
Timeline
- Start
- 2016-02
- Primary completion
- 2021-05-25
- Completion
- 2021-05-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Gabapentin | Small molecule | 800 mg | — |
| Comparator | Naltrexone | Small molecule | 6.25 mg | Oral |
| Comparator | Naltrexone | Small molecule | 25 mg | Oral |
| Comparator | Naltrexone | Small molecule | 50 mg | Oral |
| Comparator | Buprenorphine | Other / unclassified | 12 mg | — |
| Comparator | Clonidine | Other / unclassified | 0.1 mg | — |