Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery

Phase 4 Unknown 900 enrolled Oslo University Hospital Haukeland University Hospital · collab Sahlgrenska University Hospital · collab St. Olavs Hospital · collab UMC Utrecht · collab University Hospital of North Norway · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and cognitive decline in male and female participants aged 70+ scheduled for open heart surgery.

Timeline

Start: 2022-01-17
Primary completion: 2024-07
Completion: 2025-01

Publications

Neerland BE, Busund R, Haaverstad R, Helbostad JL, Landsverk SA, Martinaityte I, Norum HM, Raeder J, Selbaek G, Simpson MR, Skaar E, Skjaervold NK, Skovlund E, Slooter AJ, Svendsen OS, Tonnessen T, Wahba A, Zetterberg H, Wyller TB. Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial. BMJ Open. 2022 Jun 20;12(6):e057460. doi: 10.1136/bmjopen-2021-057460.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clonidine	Other / unclassified	0.2 ug/kg	Intravenous
Subject	Dexmedetomidine	Other / unclassified	0.2 ug/kg	Intravenous

Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery

Summary

Timeline

Publications

Drugs

Indications