drugset / Trial / NCT02953210
Laparoscopic Cholecystectomy: General Anesthesia With Opioid Versus General Opioid Free Anesthesia
Phase 4
Unknown
40 enrolled
Federal University of São Paulo
Faculdade de Ciências Médicas da Santa Casa de São Paulo · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
The use of opioid during surgery can cause side effects and may delay hospital discharge. Some studies have shown balanced sparing opioid anesthesia can optimize the side effects and and the time of discharge. In this compared controlled randomized study the aim is to evaluate the intraoperative and postoperative pain, hemodynamic effects, nausea/vomiting, postoperative ileus, sedation, urinary retention, time of discharge PACU Post anesthesia care unit and hospital.
Timeline
- Start
- 2016-11
- Primary completion
- 2016-11
- Completion
- 2017-03
Publications
- Background Bisgaard T. Analgesic treatment after laparoscopic cholecystectomy: a critical assessment of the evidence. Anesthesiology. 2006 Apr;104(4):835-46. doi: 10.1097/00000542-200604000-00030.
- Background De Oliveira GS Jr, Fitzgerald P, Streicher LF, Marcus RJ, McCarthy RJ. Systemic lidocaine to improve postoperative quality of recovery after ambulatory laparoscopic surgery. Anesth Analg. 2012 Aug;115(2):262-7. doi: 10.1213/ANE.0b013e318257a380. Epub 2012 May 14.
- Results Collard V, Mistraletti G, Taqi A, Asenjo JF, Feldman LS, Fried GM, Carli F. Intraoperative esmolol infusion in the absence of opioids spares postoperative fentanyl in patients undergoing ambulatory laparoscopic cholecystectomy. Anesth Analg. 2007 Nov;105(5):1255-62, table of contents. doi: 10.1213/01.ane.0000282822.07437.02.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clonidine | Other / unclassified | 1 ug/kg | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 3 ug/kg | Intravenous |
| Subject | Ketamine | Small molecule | 0.2 mg/kg | — |
| Subject | Lidocaine | Other / unclassified | 2 mg/kg | Intravenous |
| Background | Bupivacaine | Other / unclassified | — | Other |
| Background | Dexamethasone | Small molecule | 4 mg | Intravenous |
| Background | Isoflurane | Other / unclassified | 1 unknown | — |
| Background | Ketorolac | Other / unclassified | — | Intravenous |
| Background | Midazolam | Small molecule | 50 ug/kg | — |
| Background | Ondansetron | Other / unclassified | — | — |
| Background | Propofol | Small molecule | 2 mg/kg | — |
| Background | Ranitidine | Unknown | — | — |
| Background | Rocuronium | Other / unclassified | 0.6 mg/kg | — |