Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study

Phase 1 Completed 14 enrolled Johns Hopkins University

NaSingle-groupOpen-labelTreatment

Summary

Critically ill infants and children who are mechanically ventilated are often given large doses of opiates and benzodiazepines to provide analgesia-sedation. These drugs significantly cause tolerance and dependence, depresses the drive to breathe, and thus prolongs the need for mechanical ventilation and the associated complications. We propose IV CLON could be used as effectively as DEX.

Timeline

Start: 2015-09
Primary completion: 2019-12
Completion: 2019-12

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clonidine	Other / unclassified	—	Intravenous

Indications

No indication recorded.