Clonidine and Morphine in Caudal Anesthesia

Phase 1/2 Completed 80 enrolled Federal University of Minas Gerais Santa Casa de Misericórdia de Belo Horizonte · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Hypothesis: The combined use of Clonidine and Morphine in caudal anesthesia provides better postoperative analgesia than either drug alone after urogenital pediatric surgery.

Timeline

Start: 2008-07
Primary completion: 2008-09
Completion: 2009-09

Publications

Background Tripi PA, Palmer JS, Thomas S, Elder JS. Clonidine increases duration of bupivacaine caudal analgesia for ureteroneocystostomy: a double-blind prospective trial. J Urol. 2005 Sep;174(3):1081-3. doi: 10.1097/01.ju.0000169138.90628.b9.
Background Luz G, Innerhofer P, Oswald E, Salner E, Hager J, Sparr H. Comparison of clonidine 1 microgram kg-1 with morphine 30 micrograms kg-1 for post-operative caudal analgesia in children. Eur J Anaesthesiol. 1999 Jan;16(1):42-6. doi: 10.1046/j.1365-2346.1999.00430.x.
Background Vetter TR, Carvallo D, Johnson JL, Mazurek MS, Presson RG Jr. A comparison of single-dose caudal clonidine, morphine, or hydromorphone combined with ropivacaine in pediatric patients undergoing ureteral reimplantation. Anesth Analg. 2007 Jun;104(6):1356-63, table of contents. doi: 10.1213/01.ane.0000261521.52562.de.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Clonidine	Other / unclassified	1 ug/kg	Other
Comparator	Morphine	Other / unclassified	20 ug/kg	Other
Comparator	Bupivacaine	Other / unclassified	0.166 %	Other

Indications

No indication recorded.