Using Clonidine to Improve Leg Weakness in People With Heart Failure

Phase 4 Completed 11 enrolled University of California, Los Angeles National Heart, Lung, and Blood Institute (NHLBI) · collab

RandomizedParallel-groupQuadruple-blindBasic science

Summary

People with heart failure often have weakness in their leg muscles. This study will determine whether the leg weakness is due to very high adrenaline levels and whether the medication clonidine can improve leg weakness.

Timeline

Start: 2008-05
Primary completion: 2011-03
Completion: 2012-12

Publications

Results Middlekauff HR, Verity MA, Horwich TB, Fonarow GC, Hamilton MA, Shieh P. Intact skeletal muscle mitochondrial enzyme activity but diminished exercise capacity in advanced heart failure patients on optimal medical and device therapy. Clin Res Cardiol. 2013 Aug;102(8):547-54. doi: 10.1007/s00392-013-0564-3. Epub 2013 Apr 11.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Clonidine	Other / unclassified	0.1 mg	Other

Using Clonidine to Improve Leg Weakness in People With Heart Failure

Summary

Timeline

Publications

Drugs

Indications