drugset / Trial / NCT07097493
Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this research study is to compare two different combinations of anesthetic medications to see which works the best in providing the longest lasting pain relief for total knee arthroplasty surgery. The drugs being used are liposomal bupivacaine compared to a combination of bupivacaine, clonidine, epinephrine, buprenorphine, and dexamethasone. Pain scores will be collected at different intervals during study participation.
Timeline
- Start
- 2026-08
- Primary completion
- 2026-12-31
- Completion
- 2026-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Bupivacaine | Other / unclassified | 0.25 % | Other |
| Comparator | Bupivacaine | Other / unclassified | 133 mg | Other |
| Comparator | Buprenorphine | Other / unclassified | 0.15 mg | Other |
| Comparator | Clonidine | Other / unclassified | 1.667 ug/ml | Other |
| Comparator | Dexamethasone | Small molecule | 2 mg | Other |
| Comparator | Epinephrine | Other / unclassified | — | Other |