Neonatal Spinal Anesthesia: Effects of the Addition of Clonidine

Phase 4 Unknown 120 enrolled University Hospital, Montpellier

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This prospective, double blinded study investigates spinal anesthesia with or without clonidine added to bupivacaine in newborns. This study is based on duration measurement of spinal anesthesia and cardio respiratory recording during 24h for apnea detection.

Timeline

Start: 2006-11
Primary completion: 2006-11
Completion: 2009-12

Publications

Background Rochette A, Raux O, Troncin R, Dadure C, Verdier R, Capdevila X. Clonidine prolongs spinal anesthesia in newborns: a prospective dose-ranging study. Anesth Analg. 2004 Jan;98(1):56-59. doi: 10.1213/01.ANE.0000093229.17729.6C.
Background Rochette A, Troncin R, Raux O, Dadure C, Lubrano JF, Barbotte E, Capdevila X. Clonidine added to bupivacaine in neonatal spinal anesthesia: a prospective comparison in 124 preterm and term infants. Paediatr Anaesth. 2005 Dec;15(12):1072-7. doi: 10.1111/j.1460-9592.2005.01664.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Clonidine	Other / unclassified	1 ug/kg	Intrathecal
Background	Bupivacaine	Other / unclassified	1 mg/kg	Intrathecal

Indications

No indication recorded.