alpha-lipoic acid
Small molecule targets EGFR, TNF via inhibition
Trials 73 · started per year
Also used as a comparator or background therapy in 36 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 13 trials | ||||||
| Phase 1 | NCT01294176 Comparator | Jan 2011 → Nov 2016 | optic neuritis | Oregon Health and Science University | Completed | No outcome recorded |
| Phase 1 | NCT01258699 Comparator | Aug 2009 → ? | — | Bukwang Pharmaceutical | Completed | No outcome recorded |
| Phase 1 | NCT00676156 Comparator | Dec 2005 → Feb 2008 | multiple sclerosis | Oregon Health and Science University | Completed | No outcome recorded |
| Phase 1/21 trial | ||||||
| Phase 1/2 | NCT05507697 Comparator | May 2022 → May 2024 | diabetic polyneuropathy | Wuhan Central Hospital | Unknown | No outcome recorded |
| Phase 211 trials | ||||||
| Phase 2 | NCT07574684 Comparator | Apr 2026 → Jan 2027 expected | non-small cell lung carcinoma | Ain Shams University | Not yet recruiting | No outcome recorded |
| Phase 2 | NCT06131918 Comparator | Jan → Dec 2023 | diabetic polyneuropathy | Khyber Medical University Peshawar | Completed | No outcome recorded |
| Phase 2 | NCT03257514 Comparator | Jun 2017 → Jan 2018 | — | Ain Shams University | Completed | No outcome recorded |
| Phase 2 | NCT02760823 Comparator | May 2016 → Jan 2018 | poisoning | Heba Allah Ali Abd El-Halim Mabrouk | Unknown | No outcome recorded |
| Phase 2 | NCT03428139 Comparator | Aug 2013 → Mar 2017 | radiculopathy | Assiut University | Completed | No outcome recorded |
| Phase 2 | NCT01471652 Comparator | Mar 2012 → Feb 2013 | myalgic encephalomeyelitis/chronic fatigue syndrome | Columbia University | Withdrawn | No outcome recorded |
| Phase 2 | NCT01396733 Comparator | Apr 2011 → Dec 2012 | cancer, thyroid gland disorder | Asan Medical Center | Withdrawn | No outcome recorded |
| Phase 2 | NCT00962429 Comparator | Feb 2009 → Jan 2013 | chronic inflammatory demyelinating polyradiculoneuropathy | Oregon Health and Science University | Completed | No outcome recorded |
| Phase 2 | NCT00719706 Comparator | Aug 2008 → May 2011 | bipolar depression | Mclean Hospital | Completed | No outcome recorded |
| Phase 2 | NCT00237718 Comparator | Apr 2006 → Sep 2010 | end stage renal failure | Vanderbilt University | Completed | No outcome recorded |
| Phase 2 | NCT00308971 Comparator | Mar 2006 → Jul 2007 | chronic kidney disease | Vanderbilt University | Completed | No outcome recorded |
| Phase 2/33 trials | ||||||
| Phase 2/3 | NCT06201611 Comparator | Nov 2024 → Dec 2025 overdue | diabetic polyneuropathy | St. John's Research Institute | Recruiting | No outcome recorded |
| Phase 2/3 | NCT05023863 Comparator | Sep 2021 → May 2022 | mucositis | Ain Shams University | Unknown | No outcome recorded |
| Phase 2/3 | NCT01224353 Comparator | Nov 2010 → May 2011 | — | NovaMed Pharmaceuticals Inc. | Unknown | No outcome recorded |
| Phase 38 trials | ||||||
| Phase 3 | NCT07668141 Comparator | Jun 2026 → Jan 2027 expected | poisoning | Helwan University | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07456176 Comparator | Feb → May 2026 overdue | chronic obstructive pulmonary disease | Ain Shams University | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07399743 Comparator | Feb → Jun 2026 overdue | osteoarthritis, knee | Badr University | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07157722 Comparator | Aug → Dec 2025 overdue | beta thalassemia | Tanta University | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT05679037 Comparator | Jan 2023 → Oct 2024 | type 1 diabetes mellitus | Tanta University | Unknown | No outcome recorded |
| Phase 3 | NCT05369793 Comparator | Aug 2022 → Oct 2023 | diabetic neuropathy, type 2 diabetes mellitus | Tanta University | Completed | No outcome recorded |
| Phase 3 | NCT04041167 Comparator | Aug 2018 → Jul 2021 | ischemic stroke | Chonnam National University Hospital | Unknown | No outcome recorded |
| Phase 3 | NCT02714543 Comparator | Nov 2013 → Aug 2015 | oral submucous fibrosis | The Oxford Dental College, Hospital and Research Center, Bangalore, India | Completed | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT06151652 Comparator | Jan 2023 → Mar 2024 | atrial fibrillation | Ain Shams University | Unknown | No outcome recorded |
| Phase 4 | NCT05266794 Comparator | Jan → Apr 2019 | end stage renal failure | Ain Shams University | Completed | No outcome recorded |
| Phase 4 | NCT02439879 Comparator | Dec 2009 → Dec 2010 | diabetic polyneuropathy | Universidad Popular Autónoma del Estado de Puebla | Completed | No outcome recorded |
| Phase not applicable7 trials | ||||||
| — | NCT07381361 Comparator | Apr 2025 → Jan 2026 overdue | burning mouth syndrome | Lu Jiang | Active not recruiting | No outcome recorded |
| — | NCT06067698 Comparator | Oct 2023 → Apr 2025 overdue | ulcerative colitis | Tanta University | Recruiting | No outcome recorded |
| — | NCT05000463 Background | Feb → Aug 2022 | chronic pain syndrome | Assiut University | Unknown | No outcome recorded |
| — | NCT06195137 Comparator | Dec 2021 → Jun 2023 | burning mouth syndrome | Lu Jiang | Completed | No outcome recorded |
| — | NCT02999958 Comparator | Dec 2016 → May 2018 | — | Vitrolife | Completed | No outcome recorded |
| — | NCT00795262 Comparator | Jul 2008 → Jul 2009 | diabetes mellitus, hypertensive disorder | InVasc Therapeutics, Inc. | Completed | No outcome recorded |
| — | NCT00122447 Comparator | May 2005 → May 2011 | glucose intolerance, prediabetes syndrome | Emory University | Completed | No outcome recorded |
Evidence & citations 21 cited values
Every value below carries the sentence it was read from. 116 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | Alpha lipoic acid | “Alpha-lipoic acid (ALA) or 6,8-thioctic acid, is an endogenous molecule which functions as an important co-factor for various enzyme complexes in mitochondria and plays an...” NCT04475276 ↗101“Alpha Lipoic Acid (ALA) is a potent antioxidant and anti-inflammatory agent that scavenges reactive oxygen species, regenerates endogenous antioxidants, and modulates...” NCT07456176 ↗ “Alpha-Lipoic Acid (ALA) is a natural molecule that can make a significant contribution to the success of embryo implantation phase, because it exerts, directly or indirectly,...” NCT03023514 ↗ “Alpha-lipoic acid (Thiotacid 600 mg ®) at a dose of 600 mg three times daily for one day prior to surgery, followed by Alpha-lipoic acid 600 mg twice daily for 5 days...” NCT06151652 ↗ “Alpha-lipoic acid (ALA) is a natural short chain fatty acid containing sulfhydryl groups generated from octanoic acid and cysteine in the mitochondria, and is found in both the...” PMID 35023797 ↗ Jan 2022 “SM Fibro (Alpha lipoic acid 50mg, Beta-carotene 10mg, Elemental copper 1mg, Elemental selenium 75mcg, Lycopene 5mg, Vitamin E 10 IU, Zinc sulphate 27.45mg in form of the...” NCT02714543 ↗ “Each tablet contains 4 active ingredients as follows: Alpha lipoic acid 300mg, Vitamin B12 (methylcobalamin) 500mcg, Vitamin B6 (pyridoxine) 8mg, Vitamin B1 (thiamine) 39mg.” NCT06568185 ↗ “Nutraceuticals like alpha-lipoic acid (ALA) may have potential benefits as prophylactic agents for adolescent migraine, with fewer adverse events than existing medications.” PMID 37563914 ↗ Aug 2023 “Each capsule is a combination of vitamins and natural products: Vitamin B1 (100mg); Vitamin B6 (50mg); Niacin (200mg); Alpha Lipoic Acid (150mg); and Piperine (15mg).” NCT06242535 ↗ “We aimed to evaluate the efficacy and safety of roflumilast compared to alpha-lipoic acid (ALA) in type 2 diabetic patients with diabetic neuropathy.” PMID 41256904 ↗ Nov 2025 “We aimed to evaluate the efficacy and safety of roflumilast compared to alpha-lipoic acid (ALA) in type 2 diabetic patients with diabetic neuropathy.” PMID 41256904 ↗ Nov 2025 “N-acetylcysteine, celecoxib, vitamin E and alpha lipoic acid start day of admission (prior to conditioning regimen) and continue through day +100” NCT02171104 ↗ “One potential therapeutic is a thiol-containing compound alpha-lipoic acid (thioctic acid, 5-(1,2-dithiolan-3- yl) pentanoic acid, ALA).” NCT02910531 ↗ “Battery of nutraceuticals provided through a 12-week schedule including: Acidophilus, Alpha-Lipoic Acid, Acetyl L-Carnitine,” NCT02696512 ↗ “N-acetylcysteine, alpha lipoic acid, vitamin E, melatonin and ascorbic acid with colistin have shown promising results” NCT06650384 ↗ “Alpha-lipoic acid (ALA), also known as 1,2-dithiolane-3-pentanoic acid or thioctic acid, is found in the mitochondria.” NCT06418347 ↗ “A double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of alpha lipoic acid (ALA)” NCT05729529 ↗ “MGO cocktail containing a combination of alpha-lipoic acid, nicotinamide, thiamine, pyridoxamine, and piperine” NCT05083546 ↗ “INV-144 is a combination drug product consisting of losartan potassium (50mg) and alpha lipoic acid (600 mg)” NCT01398423 ↗ “Alpha-lipoic acid was administered intraperitoneally at a dose of 100 mg/kg, 30 minutes before reperfusion.” NCT07391709 ↗ “Alpha-Lipoic Acid (ALA) is a natural antioxidant compound which is naturally found in plant sources.” PMID 30721699 ↗ Feb 2019 “Participants in this group will be instructed to take oral capsules containing alpha-lipoic acid.” NCT06040190 ↗ “new protocol OZOCLO (alpha-lipoic acid, ozonated oil, and chlorhexidine \[CHX\] mouthwash)” NCT05211622 ↗ “alpha lipoic acid; 300mg, methylcobalamin; 500mcg, vitamin B1; 39mg and vitamin B6; 8mg” NCT06940557 ↗ “Alpha-lipoic acid administered orally at a dose of 600 mg once daily for 6 months.” NCT07630779 ↗ “Alpha-lipoic acid (ALA), a potent antioxidant with anti-inflammatory properties” NCT07574684 ↗ “the patients in this arm receive 900mg alpha-lipoic acid through NG tube.” NCT01888861 ↗ “IV Alpha Lipoic Acid 600 mg once daily will be administered prior to PCI” NCT05360602 ↗ “alpha lipoic acid (racemic) and fish oil concentrate” NCT01780974 ↗ “alpha lipoic acid, diabetic neuropathy, capsule” NCT01261143 ↗ “Dietary Supplement: Alpha lipoic acid” NCT02910531 ↗ “3. Alpha Lipoic Acid: oral tablet qd” NCT01471652 ↗ “* alpha-lipoic acid, 100 mg/ day” NCT02348125 ↗ “Magnesium plus alpha-lipoic acid” NCT02016495 ↗ “alpha lipoic acid (ALA)” NCT00033176 ↗ “alpha-Lipoic acid (ALA)” NCT02999958 ↗ |
| Known as | 1,2-dithiolane-3-pentanoic acid | “Alpha-lipoic acid (ALA) is an 8-carbon molecule first isolated from bovine liver in 1950 that can cross the blood-brain barrier. It may also be referred to as...” NCT07391709 ↗1“Alpha-lipoic acid (ALA), also known as 1,2-dithiolane-3-pentanoic acid or thioctic acid, is found in the mitochondria.” NCT06418347 ↗ |
| Known as | 5-(1,2-dithiolan-3- yl) pentanoic acid | “One potential therapeutic is a thiol-containing compound alpha-lipoic acid (thioctic acid, 5-(1,2-dithiolan-3- yl) pentanoic acid, ALA).” NCT02910531 ↗ |
| Known as | 6,8-thioctic acid | “Alpha-lipoic acid (ALA) or 6,8-thioctic acid, is an endogenous molecule which functions as an important co-factor for various enzyme complexes in mitochondria and plays an...” NCT04475276 ↗1“Alpha-lipoic acid (ALA) or 6,8-thioctic acid, is an endogenous molecule which functions as an important co-factor for various enzyme complexes in mitochondria and plays an...” NCT04064814 ↗ |
| Known as | ALA | “Alpha-lipoic acid (ALA) or 6,8-thioctic acid, is an endogenous molecule which functions as an important co-factor for various enzyme complexes in mitochondria and plays an...” NCT04475276 ↗28“Alpha Lipoic Acid (ALA) is a potent antioxidant and anti-inflammatory agent that scavenges reactive oxygen species, regenerates endogenous antioxidants, and modulates...” NCT07456176 ↗ “Alpha-Lipoic Acid (ALA) is a natural molecule that can make a significant contribution to the success of embryo implantation phase, because it exerts, directly or indirectly,...” NCT03023514 ↗ “Alpha-lipoic acid (ALA) is a natural short chain fatty acid containing sulfhydryl groups generated from octanoic acid and cysteine in the mitochondria, and is found in both the...” PMID 35023797 ↗ Jan 2022 “Oral two 300 mg ALA sustained release tablets initiated 4 days after last dose of platinum and discontinued 2 days before next scheduled platinum dose, continued for 24 weeks.” NCT00112996 ↗ “Nutraceuticals like alpha-lipoic acid (ALA) may have potential benefits as prophylactic agents for adolescent migraine, with fewer adverse events than existing medications.” PMID 37563914 ↗ Aug 2023 “Purpose: To determine whether treatment of obstructive sleep apnea (OSA) patients with a potent oral antioxidant (alpha lipoic acid, ALA) improves cardiovascular health.” NCT05009901 ↗ “Alpha-lipoic acid (ALA) is a naturally occurring compound, synthesized in the mitochondria, that is currently approved to treat diabetic neuropathic pain.” NCT03788759 ↗ “To determine the safety and tolerability of the combination of mirabegron (MG) at a dose of 50mg/d with alpha-lipoic acid (ALA) at a dose of 2400 mg/d.” NCT05713799 ↗ “We aimed to evaluate the efficacy and safety of roflumilast compared to alpha-lipoic acid (ALA) in type 2 diabetic patients with diabetic neuropathy.” PMID 41256904 ↗ Nov 2025 “The intervention under investigation is the administration of oral Alpha-Lipoic Acid (ALA) as an adjunct to standard cisplatin-based chemotherapy.” NCT07564479 ↗ “To assess the efficacy and safety of α-lipoic acid (ALA) over 20 weeks, we conducted a multicenter randomized withdrawal open-label study” PMID 26345602 ↗ Aug 2015 “Participants will be prescribed 600 mg/day ALA (thiotacid) orally, for 3 months, and will be advised not to discontinue this medication” NCT04322240 ↗ “Alpha Lipoic acid (ALA) (Thiotex fort®) 600mg once daily with their routine therapy just after the dialysis sessions for 3 months.” NCT05266794 ↗ “Alpha-lipoic acid (ALA) was proposed as a new approach in schizophrenia to improve metabolic effects of atypical antipsychotics.” PMID 35992380 ↗ Jun 2022 “Alpha-lipoic acid (ALA) known as thioctic acid "600 mg twice daily "is an organosulfur compound found in the mitochondria” NCT06650384 ↗ “A double-blind placebo-controlled trial is conducted in order to evaluate the efficacy of alpha lipoic acid (ALA)” NCT05729529 ↗ “Then they took α-lipoic acid (ALA) 3 times a day, after meals, 200 mg each time, for 2 consecutive weeks.” NCT07381361 ↗ “e.g. melatonin, N-acetyl cysteine (NAC) and alpha lipoic acid (ALA) to prevent colistin nephrotoxicity.” NCT07668141 ↗ “Alpha-Lipoic Acid (ALA) is a natural antioxidant compound which is naturally found in plant sources.” PMID 30721699 ↗ Feb 2019 “Alpha Lipoic Acid (ALA) is a drug which has been used in treatment of diabetic neuropathy” NCT05023863 ↗ “Alpha lipoic acid (ALA) 600 mg will be administered orally once daily for 12 weeks.” NCT07157722 ↗ “Alpha-lipoic acid (ALA), a potent antioxidant with anti-inflammatory properties” NCT07574684 ↗ “NAC (N-acetyl cysteine), Alpha lipoic acid (ALA), liposomal glutathione (GSH)” NCT05371288 ↗ “alpha lipoic acid (ALA) and vitamin B complex” NCT06940557 ↗ “Alpha-Lipoic Acid (ALA)+PT” NCT07399743 ↗ “alpha-lipoic acid (ALA)” NCT00719706 ↗ “Alpha lipoic acid (ALA)” NCT00122447 ↗ “alpha lipoic acid (ALA)” NCT00033176 ↗ |
| Known as | Alpha lipoic acid 600 mg oral Tablet, Nutricost pharmacetics | “Alpha lipoic acid 600 mg oral Tablet, Nutricost pharmacetics” NCT07182526 ↗ |
| Known as | alpha-Lipoic acid (ALA) | “alpha-Lipoic acid (ALA)” NCT02999958 ↗ |
| Known as | Lipoic acid | “HSK16149 20mg BID with L-carnitine hydrochloride tablets 2 tablets TID ；Lipoic acid tablets 2 tablets BID with L-carnitine hydrochloride tablets 2 tablets TID；” NCT06122012 ↗14“The medical treatment included optimal glycemic control, vitamin B complex, a lipoic acid, selective serotonin reuptake inhibitors, and pregabalin.” NCT05000463 ↗ |
| Known as | R lipoic acid | ClinicalTrials.gov intervention name — accepted as the source's own label NCT00676156 ↗ |
| Known as | Thiocacid | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01258699 ↗ |
| Known as | Thioctacid | “ALA tab 300 mg BID (Thioctacid) + PT” NCT07399743 ↗1“Alpha Lipoic Acid (Thioctacid)” NCT02760823 ↗ |
| Known as | thioctic acid | “Alpha-lipoic acid (ALA) is an 8-carbon molecule first isolated from bovine liver in 1950 that can cross the blood-brain barrier. It may also be referred to as...” NCT07391709 ↗3“One potential therapeutic is a thiol-containing compound alpha-lipoic acid (thioctic acid, 5-(1,2-dithiolan-3- yl) pentanoic acid, ALA).” NCT02910531 ↗ “Alpha-lipoic acid (ALA) known as thioctic acid "600 mg twice daily "is an organosulfur compound found in the mitochondria” NCT06650384 ↗ “Alpha-lipoic acid (ALA), also known as 1,2-dithiolane-3-pentanoic acid or thioctic acid, is found in the mitochondria.” NCT06418347 ↗ |
| Known as | thioctic acid acid | “alpha lipoic acid drug (thioctic acid acid)” NCT07668141 ↗1“alpha lipoic acid drug (thioctic acid acid)” NCT03257514 ↗ |
| Known as | Thiotacid | “Alpha-lipoic acid (Thiotacid 600 mg ®) at a dose of 600 mg three times daily for one day prior to surgery, followed by Alpha-lipoic acid 600 mg twice daily for 5 days...” NCT06151652 ↗1“alpha lipoic acid drug (thiotacid film coated tablets 600 mg)” NCT03257514 ↗ |
| Known as | Thiotex fort | “Alpha Lipoic acid (ALA) (Thiotex fort®) 600mg once daily with their routine therapy just after the dialysis sessions for 3 months.” NCT05266794 ↗ |
| Known as | α-LA | “the viability of alpha-lipoic acid (α-LA) in ensuring against carbon tetrachloride (CCl4)-actuated liver fibrosis and the mechanism(s) involved in this defensive impact were...” PMID 29233029 ↗ Feb 20171“Alpha-Lipoic Acid(α-LA)” NCT03491969 ↗ |
| Known as | α-lipoic acid | “A previous open-label study with α-lipoic acid (ALA), a potent antioxidant, improved patients' negative and cognitive symptoms and markers of lipid peroxidation.” PMID 36584248 ↗ Jan 20234“To assess the efficacy and safety of α-lipoic acid (ALA) over 20 weeks, we conducted a multicenter randomized withdrawal open-label study” PMID 26345602 ↗ Aug 2015 “Then they took α-lipoic acid (ALA) 3 times a day, after meals, 200 mg each time, for 2 consecutive weeks.” NCT07381361 ↗ “α-lipoic acid - intravenous infusion of 600 mg in 250 ml saline solution over 30 minutes” NCT00490867 ↗ “900 mg/d of α-lipoic acid (E/C/ALA)” PMID 22431837 ↗ Jul 2012 |
| Action | Inhibit | “Alpha -Lipoic acid significantly inhibits production of nitric oxide and TNF-alpha.” NCT04475276 ↗ |
| Modality | Small molecule | “naturally occurring dithiol compound” NCT01056497 ↗ |
| Route | Oral | “daily oral alpha-lipoic acid supplements” NCT00079807 ↗ |
| Target | TNF | “Alpha -Lipoic acid significantly inhibits production of nitric oxide and TNF-alpha.” NCT04475276 ↗ |