Alpha Lipoic Acid Plus Coenzyme Q10 Versus Coenzyme Q10 Alone in Asthenozoospermia
Summary
The goal of the clinical trial is to learn if Alpha-lipoic acid plus Coenzymeq10 work to treat asthenozoospermia in subfertile male. It will also learn about the safety of drug Alpha-lipoic acid plus Coenzymeq10. The main queations it aim to answer are: Does drug Alpha-lipoic acid plus CoenzymeQ10 increase sperm motility in participents? What medical problems do participants have when taking Alpha-lipoic acid plus Coenzymeq10? Reseachers will compare drug Alpha-lipoic acid plus Coenzymeq10 combination to Coenzymeq10 alone to see if alpha-lipoic acid plus Coenzymeq10 combination drugs work better. Participants will experimental group: Alpha-lipoic acid 500mg once daily plus coenzymeq10 100mg twice daily for 3 months. Comparator group: CoenzymeQ10 100mg twice daily for 3 months. visit the clinic after 3 monyhs of treatment for check up and tests.
Timeline
- Start
- 2024-07-01
- Primary completion
- 2026-01-01
- Completion
- 2026-01-01
Publications
- Results Hodeeb YM, El-Rewiny EM, Gaafar AM, Zayed AN, Hasan MS, Elsaie ML. The effect of alpha lipoic acid supplementation on sperm functions in idiopathic asthenozoospermic patients: a case-controlled study. Hum Fertil (Camb). 2023 Dec;26(5):949-957. doi: 10.1080/14647273.2021.2025271. Epub 2022 Jan 13.
- Results Haghighian HK, Haidari F, Mohammadi-Asl J, Dadfar M. Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men. Fertil Steril. 2015 Aug;104(2):318-24. doi: 10.1016/j.fertnstert.2015.05.014. Epub 2015 Jun 11.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | alpha-lipoic acid | Small molecule | 500 mg | — |
| Background | Coenzyme Q10 | Other / unclassified | 100 mg | — |