drugset / Trial / NCT07076069
The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair
RandomizedParallel-groupOpen-labelSupportive care
Summary
The goal of this clinical trial is to understand which group of pain control medications work best in adults after rotator cuff surgery.
Timeline
- Start
- 2025-07-21
- Primary completion
- 2028-06
- Completion
- 2028-06
Publications
- Background Jones MR, Viswanath O, Peck J, Kaye AD, Gill JS, Simopoulos TT. A Brief History of the Opioid Epidemic and Strategies for Pain Medicine. Pain Ther. 2018 Jun;7(1):13-21. doi: 10.1007/s40122-018-0097-6. Epub 2018 Apr 24.
- Background Storesund A, Krukhaug Y, Olsen MV, Rygh LJ, Nilsen RM, Norekval TM. Females report higher postoperative pain scores than males after ankle surgery. Scand J Pain. 2016 Jul;12:85-93. doi: 10.1016/j.sjpain.2016.05.001. Epub 2016 May 27.
- Background Hah JM, Bateman BT, Ratliff J, Curtin C, Sun E. Chronic Opioid Use After Surgery: Implications for Perioperative Management in the Face of the Opioid Epidemic. Anesth Analg. 2017 Nov;125(5):1733-1740. doi: 10.1213/ANE.0000000000002458.
- Background Moutzouros V, Jildeh TR, Khalil LS, Schwartz K, Hasan L, Matar RN, Okoroha KR. A Multimodal Protocol to Diminish Pain Following Common Orthopedic Sports Procedures: Can We Eliminate Postoperative Opioids? Arthroscopy. 2020 Aug;36(8):2249-2257. doi: 10.1016/j.arthro.2020.04.018. Epub 2020 Apr 28.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 975 mg | — |
| Subject | Celecoxib | Other / unclassified | 400 mg | — |
| Subject | Dexamethasone | Small molecule | 0.1 mg/kg | Intravenous |
| Subject | Ibuprofen | Small molecule | 600 mg | — |
| Subject | Magnesium Sulfate | Other / unclassified | 400 mg | — |
| Subject | Meloxicam | Small molecule | 7.5 mg | — |
| Subject | Pregabalin | Small molecule | 50 mg | — |
| Subject | Ropivacaine | Other / unclassified | 20 ml | Other |
| Background | Oxycodone | Other / unclassified | 5 mg | — |