Drugs / Magnesium
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Magnesium

Other / unclassified

Developed for
coronary artery disorder · major depressive disorder · neuropathy, painful · alcohol withdrawal · alcohol-induced disorders · asthma · autism spectrum disorder · bipolar I disorder
+23 more · cardiac rhythm disease · epilepsy · heart valve disorder · magnesium deficiency · migraine disorder · migraine without aura · mixed anxiety and depressive disorder · myocardial infarction · noise induced hearing loss · non-small cell lung carcinoma · osteoporosis · pancreatitis · peripheral neuropathy · pregnancy disorder · sickle cell disease · temporomandibular joint disorder · atrial fibrillation · autism spectrum disorder 1 · cisplatin toxicity · delirium · subacute delirium · thyroid cancer · tinnitus
Investigated by
University Hospital, Clermont-Ferrand · University of Michigan · AGUNCO Obstetrics and Gynecology Centre · Ain Shams University · Ann & Robert H Lurie Children's Hospital of Chicago · Assistance Publique - Hôpitaux de Paris
+46 more · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh · Cancer Institute of the State of São Paulo · Children's Hospital Medical Center, Cincinnati · Fayoum University · Finnish Foundation for Alcohol Studies · Hasanuddin University · Hearing Health Science, Inc. · Heart and Stroke Foundation of Canada · Hospital Odontològic UB · Hospital Universitario La Fe · Hospital Universitario Rey Juan Carlos · IndiPharm Inc. · Istanbul University · MIPO Clinic · Mayo Clinic · Mclean Hospital · Ministry of Health, France · Montefiore Medical Center · National Cancer Institute, Egypt · National Center for Complementary and Integrative Health (NCCIH) · National Center for Research Resources (NCRR) · National Heart, Lung, and Blood Institute (NHLBI) · National Institute on Deafness and Other Communication Disorders (NIDCD) · Navitas Pharma · Renal Research Institute · Sir Charles Gairdner Hospital · Southern Illinois University · Spherium Biomed · Stanford University · Tanta University · The Catholic University of Korea · The Hospital for Sick Children · Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude · Universitat Internacional de Catalunya · University Hospital, Basel, Switzerland · University Hospitals Cleveland Medical Center · University Medicine Greifswald · University of British Columbia · University of Catanzaro · University of Child Health Sciences and Children's Hospital, Lahore · University of Florida · University of Roma La Sapienza · University of Tennessee · Wake Forest University Health Sciences · Yeditepe University Hospital · Yonsei University

Trials 41

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03879707 Jun 2025 → Jun 2028 — Stanford University Withdrawn No outcome recorded
Phase 13 trials · 1 met primary
Phase 1 NCT06209229 May 2022 → May 2023 non-small cell lung carcinoma MIPO Clinic Completed No outcome recorded
Phase 1 NCT04532775 Aug → Dec 2020 peripheral neuropathy Fayoum University Unknown Met primary
Phase 1 NCT00346658 Jul 2002 → Sep 2006 osteoporosis University of Tennessee Completed No outcome recorded
Phase 1/22 trials
Phase 1/2 NCT02709031 Jun 2022 → Jun 2024 diabetes mellitus, hypertensive disorder, potassium deficiency Navitas Pharma Unknown No outcome recorded
Phase 1/2 NCT02602483 Dec 2015 → Dec 2016 temporomandibular joint disorder Spherium Biomed Completed No outcome recorded
Phase 211 trials · 1 missed
Phase 2 NCT07458022 Dec 2025 → Apr 2026 overdue major depressive disorder University of Child Health Sciences and Children's Hospital, Lahore Active not recruiting No outcome recorded
Phase 2 NCT05837104 Dec 2023 → Oct 2026 expected bipolar I disorder, mixed anxiety and depressive disorder Mclean Hospital Recruiting No outcome recorded
Phase 2 NCT05806996 Jul 2023 → Jun 2026 overdue — Mayo Clinic Recruiting No outcome recorded
Phase 2 NCT03963479 Jan → Jul 2019 autism spectrum disorder Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Unknown No outcome recorded
Phase 2 NCT03082625 May 2017 → Mar 2018 end stage renal failure Sir Charles Gairdner Hospital Unknown No outcome recorded
Phase 2 NCT03063931 Mar 2017 → Mar 2019 — University Hospital, Clermont-Ferrand Unknown No outcome recorded
Phase 2 NCT01148888 Jun 2010 → Jun 2012 scoliosis The Hospital for Sick Children Completed No outcome recorded
Phase 2 NCT00808470 Oct 2008 → Dec 2013 noise induced hearing loss University of Michigan Completed Missed primary
Phase 2 NCT00242164 Nov 2005 → Jun 2006 cardiac rhythm disease, chronic kidney disease University of Michigan Completed No outcome recorded
Phase 2 NCT00276146 May 2005 → ? sickle cell disease Children's Hospital Medical Center, Cincinnati Withdrawn No outcome recorded Stop: Enrollment
Phase 2/31 trial
Phase 2/3 NCT02218424 Oct 2014 → Apr 2015 — Ann & Robert H Lurie Children's Hospital of Chicago Completed No outcome recorded
Phase 35 trials
Phase 3 NCT06904287 Dec 2025 → Jun 2027 expected migraine disorder Wake Forest University Health Sciences Recruiting No outcome recorded
Phase 3 NCT03033823 Nov 2017 → Oct 2020 alcohol withdrawal Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT00142233 Jun 2005 → Sep 2019 pancreatitis University Medicine Greifswald Completed No outcome recorded
Phase 3 NCT00250965 Jul 2004 → Sep 2008 coronary artery disorder, heart valve disorder University of British Columbia Terminated No outcome recorded
Phase 3 NCT00000610 Apr 1998 → Nov 2003 coronary artery disorder, myocardial infarction, myocardial ischemia National Heart, Lung, and Blood Institute (NHLBI) Completed No outcome recorded
Phase 48 trials · 1 missed
Phase 4 NCT07076069 Jul 2025 → Jun 2028 expected rotator cuff syndrome Montefiore Medical Center Recruiting No outcome recorded
Phase 4 NCT05947760 Mar 2025 → Aug 2026 overdue neuropathy, painful University Hospitals Cleveland Medical Center Active not recruiting No outcome recorded
Phase 4 NCT01756209 Jan 2010 → Feb 2012 migraine without aura University of Catanzaro Completed No outcome recorded
Phase 4 NCT02508857 Jan 2010 → Jan 2014 — Cancer Institute of the State of São Paulo Completed No outcome recorded
Phase 4 NCT00994981 Sep 2007 → Sep 2008 — The Catholic University of Korea Completed No outcome recorded
Phase 4 NCT01121653 Mar 2006 → Jan 2008 neuropathy, painful University Hospital, Clermont-Ferrand Completed No outcome recorded
Phase 4 NCT00325299 ? → Sep 2005 alcohol-induced disorders Finnish Foundation for Alcohol Studies Completed Missed primary
Phase 4 NCT02016495 ? → Feb 2013 pregnancy disorder AGUNCO Obstetrics and Gynecology Centre Completed No outcome recorded
Phase not applicable10 trials
— NCT07305519 Apr 2026 → Apr 2027 expected — University of Roma La Sapienza Recruiting No outcome recorded
— NCT07082894 Jul 2025 → Apr 2026 — Tanta University Completed No outcome recorded
— NCT07521358 Jul → Aug 2025 major depressive disorder Hasanuddin University Completed No outcome recorded
— NCT05851768 May 2023 → Nov 2026 expected — National Cancer Institute, Egypt Recruiting No outcome recorded
— NCT05485480 Nov 2022 → Feb 2024 — University Hospital, Basel, Switzerland Completed No outcome recorded
— NCT04626063 Jun 2018 → Mar 2019 — Istanbul University Completed No outcome recorded
— NCT03355807 Jan → Dec 2017 opioid-induced constipation Yeditepe University Hospital Completed No outcome recorded
— NCT02982824 Sep 2016 → Feb 2017 epilepsy Ain Shams University Completed No outcome recorded
— NCT01679353 Sep → Dec 2012 — Yonsei University Completed No outcome recorded
— NCT01700998 Sep 2012 → Oct 2014 magnesium deficiency Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude Completed No outcome recorded
Comparator or background therapy24 trials
Phase 1/2 NCT06077539 Comparator Sep 2023 → Apr 2024 subacute delirium Cairo University Unknown No outcome recorded
Phase 1/2 NCT01146197 Background Feb 2010 → Dec 2012 Gitelman syndrome Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 2 NCT06810765 Background Sep 2025 → Dec 2026 cognitive disorder, post-traumatic stress disorder, traumatic brain injury Johns Hopkins University Withdrawn No outcome recorded
Phase 2 NCT05586009 Comparator Oct 2022 → Feb 2025 cisplatin toxicity Tanta University Completed No outcome recorded
Phase 2 NCT03223519 Comparator Jul → Nov 2017 — Spherium Biomed Completed No outcome recorded

Evidence & citations 6 cited values

Every value below carries the sentence it was read from. 66 sources stand behind the page.

FieldValueCited text
Known as magnesium “This study proposes a randomized, double-blind, placebo-controlled crossover trial to assess the effects of a prophylactic combination of N-acetylcysteine (600 mg) and...” PMID 24708640 ↗ Apr 2014
64

“Anesthesia will be maintained with Sevoflurane, Magnesium, Lidocaine, Ketamine, Decadron, Ondansetron, and Ketorolac at a concentration range/dose(s) based on the clinical need...” NCT03367988 ↗

“In addition to propofol as a hypnotic and rocuronium as a muscle relaxant, patients in the opioid-sparing group will receive Ketamine, Fentanyl, Lidocaine, Magnesium,...” NCT05485480 ↗

“Intraoperatively: Intravenous Dexamethasone 0.1mg/kg (maximum dose of 8mg), Magnesium 2g, Acetaminophen 1000mg, and local infiltration of 0.5% Ropivacaine 20ml” NCT07076069 ↗

“Magnesium supplementation administered orally at a dose of 350 mg once daily as adjunct therapy to fluoxetine for 6 weeks.” NCT07521358 ↗

“A bolus dose of magnesium of 50 mg/kg will be administered within 10 minutes preoperatively diluted in 100 mL of saline.” NCT04622904 ↗

“Magnesium (in the form of lactate dihydrate) 470 mg + pyridoxine (in the form of hydrochloride) 5 mg - take orally” NCT06209229 ↗

“Triple combination of Ibuprofen, Magnesium and Vitamin C Powder for oral solution administered TID for 3 days” NCT03223519 ↗

“Magnesium 50mg (Magnesium 10% 0.5mL)added to ropivacaine 0.15% 1.0ml/kg to Group MR.” NCT01679353 ↗

“a supplementation with potassium and magnesium will be orally given” NCT01146197 ↗

“Magnesium plus alpha-lipoic acid” NCT02016495 ↗

Show 54 more sources

Known as Magnogene “Magnogene ® (magnesium)” NCT01121653 ↗
Known as Magnésium UPSA Action Continue “Magnesium: Magnésium UPSA Action Continue®” NCT03063931 ↗
Action Inhibit “Magnesium is considered to be "nature's physiologic calcium blocker."” NCT00000610 ↗
Modality Other / unclassified “As a physiological blocker of NMDAR, magnesium could be an interesting candidate to prevent postoperative pain and associated comorbidities, including cognitive and emotional...” PMID 30287600 ↗ Oct 2018
Route Intravenous “intravenous bolus of magnesium sulphate administered over 15 minutes” NCT00000610 ↗