Magnesium in Coronaries (MAGIC)

Summary

To determine whether early intravenous magnesium treatment of patients with suspected acute myocardial infarction reduces mortality.

Timeline

Start

1998-04

Primary completion

—

Completion

2003-11

Publications

• Background MAGIC Steering Committee. Rationale and design of the magnesium in coronaries (MAGIC) study: A clinical trial to reevaluate the efficacy of early administration of magnesium in acute myocardial infarction. Am Heart J. 2000 Jan;139(1 Pt 1):10-4.
• Background Magnesium in Coronaries (MAGIC) Trial Investigators. Early administration of intravenous magnesium to high-risk patients with acute myocardial infarction in the Magnesium in Coronaries (MAGIC) Trial: a randomised controlled trial. Lancet. 2002 Oct 19;360(9341):1189-96. doi: 10.1016/s0140-6736(02)11278-5.
• Background Domanski M, Antman EM, McKinlay S, Varshavsky S, Platonov P, Assmann SF, Norman J. Geographic variability in patient characteristics, treatment and outcome in an International Trial of Magnesium in acute myocardial infarction. Control Clin Trials. 2004 Dec;25(6):553-62. doi: 10.1016/j.cct.2004.08.005.
• Background Cooper HA, Domanski MJ, Rosenberg Y, Norman J, Scott JH, Assmann SF, McKinlay SM, Hochman JS, Antman EM; Magnesium in Coronaries trial investigators. Acute ST-segment elevation myocardial infarction and prior stroke: an analysis from the Magnesium in Coronaries (MAGIC) trial. Am Heart J. 2004 Dec;148(6):1012-9. doi: 10.1016/j.ahj.2004.02.017.

Drugs

Indications