drugset / Trial / NCT01638962
The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT
Completed
93 enrolled
University of Southern Denmark
Association of Danish Physiotherapists · collabOdense University Hospital · collabRegion Syddanmark · collabThe Danish Rheumatism Association · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
The purpose of this study is to compare the effects of neuromuscular exercise and analgesic use on knee joint load, in patients with mild to moderate knee osteoarthritis (OA). It is expected that the two groups will receive equipotent pain relieving effect, despite this, the investigators expect a between group difference in knee joint load, and the exercise group will have a reduction in knee joint load.
Timeline
- Start
- 2012-08
- Primary completion
- 2015-08
- Completion
- 2016-07
Publications
- Background Thorstensson CA, Henriksson M, von Porat A, Sjodahl C, Roos EM. The effect of eight weeks of exercise on knee adduction moment in early knee osteoarthritis--a pilot study. Osteoarthritis Cartilage. 2007 Oct;15(10):1163-70. doi: 10.1016/j.joca.2007.03.012. Epub 2007 Apr 26.
- Background Ageberg E, Link A, Roos EM. Feasibility of neuromuscular training in patients with severe hip or knee OA: the individualized goal-based NEMEX-TJR training program. BMC Musculoskelet Disord. 2010 Jun 17;11:126. doi: 10.1186/1471-2474-11-126.
- Holsgaard-Larsen A, Christensen R, Clausen B, Sondergaard J, Andriacchi TP, Roos EM. One year effectiveness of neuromuscular exercise compared with instruction in analgesic use on knee function in patients with early knee osteoarthritis: the EXERPHARMA randomized trial. Osteoarthritis Cartilage. 2018 Jan;26(1):28-33. doi: 10.1016/j.joca.2017.10.015. Epub 2017 Oct 26.
- Holsgaard-Larsen A, Clausen B, Sondergaard J, Christensen R, Andriacchi TP, Roos EM. The effect of instruction in analgesic use compared with neuromuscular exercise on knee-joint load in patients with knee osteoarthritis: a randomized, single-blind, controlled trial. Osteoarthritis Cartilage. 2017 Apr;25(4):470-480. doi: 10.1016/j.joca.2016.10.022. Epub 2016 Nov 9.
- Clausen B, Holsgaard-Larsen A, Sondergaard J, Christensen R, Andriacchi TP, Roos EM. The effect on knee-joint load of instruction in analgesic use compared with neuromuscular exercise in patients with knee osteoarthritis: study protocol for a randomized, single-blind, controlled trial (the EXERPHARMA trial). Trials. 2014 Nov 15;15:444. doi: 10.1186/1745-6215-15-444.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | — | — |
| Comparator | Aspirin | Small molecule | — | Oral |
| Comparator | Celecoxib | Other / unclassified | — | Oral |
| Comparator | Dexibuprofen | Small molecule | — | Oral |
| Comparator | Dexketoprofen | Small molecule | — | Oral |
| Comparator | Diclofenac | Other / unclassified | — | Oral |
| Comparator | Etodolac | Unknown | — | Oral |
| Comparator | Etoricoxib | Small molecule | — | Oral |
| Comparator | Ibuprofen | Small molecule | — | Oral |
| Comparator | Indomethacin | Small molecule | — | Oral |
| Comparator | Lornoxicam | Small molecule | — | Oral |
| Comparator | Meloxicam | Small molecule | — | Oral |
| Comparator | Nabumetone | Small molecule | — | Oral |
| Comparator | Naproxen | Small molecule | — | Oral |
| Comparator | Tenoxicam | Other / unclassified | — | Oral |
| Comparator | Tiaprofenic acid | Small molecule | — | Oral |