Indomethacin

also known as indometacin · CHRONO-INDOCID · Extended-release indomethacin · IND · INDO · Indom · Indomethacin 5 MG/ML Ophthalmic Suspension

Small molecule

Developed for: patent ductus arteriosus · acute pancreatitis · pancreatitis · COVID-19 · intracerebral hemorrhage · obstetric disorder · Alzheimer disease · autoinflammatory syndrome
+31 more
· autonomic nervous system disorder · carcinoma of soft palate · cardiac rhythm disease · cervical incompetence · chronic pancreatitis · colorectal cancer · colorectal neoplasm · cutaneous melanoma · enuresis · epicondylitis · Gitelman syndrome · gout · hand-foot syndrome · hemorrhagic disease · hyalitis · Langerhans cell histiocytosis · macular retinal edema · metastatic prostate carcinoma · neoplasm of esophagus · oral cavity squamous cell carcinoma · orthostatic hypotension · ovarian neoplasm · pancreas disorder · periventricular leukomalacia · preterm premature rupture of the membranes · prostate adenocarcinoma · respiratory system disorder · ankylosing spondylitis · asthma · osteoarthritis · spondyloarthropathy
Investigated by: Iroko Pharmaceuticals, LLC · National Heart, Lung, and Blood Institute (NHLBI) · Shaare Zedek Medical Center · University of Wisconsin, Madison · University of California, San Francisco · Air Force Military Medical University, China
+98 more
· Brock University · Changhai Hospital · National Cancer Institute (NCI) · National Institutes of Health (NIH) · University of Brescia · American College of Gastroenterology · American Health Assistance Foundation · Assistance Publique - Hôpitaux de Paris · Assiut University · Athena Medical Group · Azad University of Medical Sciences · Bausch & Lomb Incorporated · Bayer · Beth Israel Deaconess Medical Center · CEL-SCI Corporation · Cairo University · China Medical University Hospital · Chinese University of Hong Kong · Dartmouth-Hitchcock Medical Center · David Vitale MD · Eastern Hepatobiliary Surgery Hospital · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · First People's Hospital of Hangzhou · Genfit · GlaxoSmithKline · Göteborg University · Hadassah Medical Organization · Health Sciences Centre, Winnipeg, Manitoba · Histiocyte Society · Hong Huang · Hospital General de Chihuahua - Dr. Salvador Zubirán Anchondo · Indiana University · Institute of Liver and Biliary Sciences, India · Janssen Research & Development, LLC · Janssen Scientific Affairs, LLC · Kowa Research Institute, Inc. · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Maastricht University Medical Center · Mamta Parikh · Mayo Clinic · Medical Research Council of Canada · Medical University of South Carolina · Mexican Social Security Institute · NICHD Neonatal Research Network · National Center for Advancing Translational Sciences (NCATS) · National Center for Research Resources (NCRR) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Taiwan University Hospital · National University of Singapore · Netherlands Alzheimer Foundation · Netherlands Brain Foundation · North American Consortium for Histiocytosis · Northwestern University · Organon and Co · Orient Europharma Co., Ltd. · Peking Union Medical College Hospital · Perseverance Research Center, LLC · Pontificia Universidad Catolica de Chile · Queen's University · Radboud University Medical Center · Rundo International Pharmaceutical Research & Development Co.,Ltd. · Saint Thomas Hospital, Panama · Sandoz · Sara Varea · Satish R. Raj · Second Affiliated Hospital, School of Medicine, Zhejiang University · Sen-Jam Pharmaceutical · Shanghai Jiao Tong University School of Medicine · Sheba Medical Center · Sint Maartenskliniek · Soroka University Medical Center · St. Boniface Hospital · St. Luke's Medical Center · Teva Branded Pharmaceutical Products R&D, Inc. · all 104 on the full record

Regulatory milestones approvals, filings & regulatory actions · 2 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Label expansion	US (FDA)	INDOCIN	—	1986-01-06	fda.gov ↗
Approved	US (FDA)	INDOCIN	—	1965-06-10	fda.gov ↗

Trials 85 · started per year

today

US approved 1965

196419651966196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 05 trials
Phase 0	NCT07218653	Jul 2026 → Jul 2031 expected	metabolic syndrome X	University of Wisconsin, Madison	Not yet recruiting	No outcome recorded
Phase 0	NCT04265053	Apr 2021 → Mar 2025	cerebral arterial disease	University of Wisconsin, Madison	Completed	No outcome recorded
Phase 0	NCT04821323	Mar → May 2021	—	Janssen Research & Development, LLC	Completed	No outcome recorded
Phase 0	NCT02653638	Jun 2016 → Apr 2019	cerebrovascular disorder	University of Wisconsin, Madison	Completed	No outcome recorded
Phase 0	NCT00943345	Sep 2009 → Feb 2012	digestive system disorder	Maastricht University Medical Center	Unknown	No outcome recorded
Phase 14 trials
Phase 1	NCT03985969	Sep 2019 → Mar 2020	—	Genfit	Completed	No outcome recorded
Phase 1	NCT01719926	Sep 2012 → Aug 2017	colorectal neoplasm, neoplasm of esophagus, ovarian neoplasm	UMC Utrecht	Completed	No outcome recorded
Phase 1	NCT00858195	Jun → Jul 2006	—	Sandoz	Completed	No outcome recorded
Phase 1	NCT00223691	Mar 2002 → Jan 2017	autonomic nervous system disorder, orthostatic hypotension	Vanderbilt University	Completed	No outcome recorded
Phase 1/27 trials
Phase 1/2	NCT04207060	Jul 2020 → Apr 2023	chronic pancreatitis	Mayo Clinic	Completed	No outcome recorded
Phase 1/2	NCT04344457	Apr → Jun 2020	COVID-19	Perseverance Research Center, LLC	Unknown	No outcome recorded
Phase 1/2	NCT02935205	Jan 2017 → Mar 2024	metastatic prostate carcinoma	Mamta Parikh	Unknown	No outcome recorded
Phase 1/2	NCT02221219	Aug 2014 → Oct 2019	brain injury, intracerebral hemorrhage, periventricular leukomalacia	Hong Huang	Completed	No outcome recorded
Phase 1/2	NCT01280006	Jan → Dec 2011	hypertensive disorder, obstructive sleep apnea syndrome, stroke disorder	University of Calgary	Completed	No outcome recorded
Phase 1/2	NCT01146197	Feb 2010 → Dec 2012	Gitelman syndrome	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 1/2	NCT00262470	Apr 1997 → Dec 2029 expected	cardiac rhythm disease	Satish R. Raj	Active not recruiting	No outcome recorded
Phase 217 trials
Phase 2	NCT07560566	Dec 2025 → Apr 2029 expected	hand-foot syndrome, hepatocellular carcinoma	National Taiwan University Hospital	Recruiting	No outcome recorded
Phase 2	NCT06572917	Nov 2025 → Dec 2028 expected	intracerebral hemorrhage	University of British Columbia	Not yet recruiting	No outcome recorded
Phase 2	NCT05722548	Feb → Dec 2023	pancreas disorder	Shanghai Jiao Tong University School of Medicine	Unknown	No outcome recorded
Phase 2	NCT04025177	Jan 2020 → Aug 2021	patent ductus arteriosus	University of Manitoba	Withdrawn	No outcome recorded
Phase 2	NCT03562624	Jun 2018 → May 2019	—	Bayer	Completed	No outcome recorded
Phase 2	NCT02849990	Mar 2017 → Dec 2018	prostate adenocarcinoma	University of Washington	Completed	No outcome recorded
Phase 2	NCT02633969	Dec 2015 → Jan 2017	—	Iroko Pharmaceuticals, LLC	Completed	No outcome recorded
Phase 2	NCT01958320	Dec 2013 → Jun 2017	intestinal perforation, necrotizing enterocolitis, patent ductus arteriosus	University of California, San Francisco	Completed	No outcome recorded
Phase 2	NCT01291654	Apr 2012 → Dec 2014	patent ductus arteriosus	Shaare Zedek Medical Center	Unknown	No outcome recorded
Phase 2	NCT01577121	Apr 2012 → Sep 2014	—	Sara Varea	Completed	No outcome recorded
Phase 2	NCT01070745	Jun 2010 → Jun 2012	patent ductus arteriosus	Shaare Zedek Medical Center	Withdrawn	No outcome recorded
Phase 2	NCT00964431	Aug → Dec 2009	—	Iroko Pharmaceuticals, LLC	Completed	No outcome recorded
Phase 2	NCT00722033	Aug 2008 → Aug 2009	—	Pontificia Universidad Catolica de Chile	Unknown	No outcome recorded
Phase 2	NCT00616382	Mar 2008 → Mar 2010	patent ductus arteriosus	Shaare Zedek Medical Center	Unknown	No outcome recorded
Phase 2	NCT00466128	Apr 2007 → Apr 2015	preterm premature rupture of the membranes	Thomas Jefferson University	Unknown	No outcome recorded
Phase 2	NCT00187447	Aug 2003 → Jul 2006	patent ductus arteriosus	University of California, San Francisco	Completed	No outcome recorded
Phase 2	NCT00002535	Jul 1993 → Jul 2004	cutaneous melanoma	St. Luke's Medical Center	Completed	No outcome recorded

Phase 2/34 trials
Phase 2/3	NCT04404686	Oct 2020 → Apr 2024	obstetric disorder	Hadassah Medical Organization	Unknown	No outcome recorded
Phase 2/3	NCT02205762	Nov 2016 → Jul 2026 overdue	Langerhans cell histiocytosis	North American Consortium for Histiocytosis	Active not recruiting	No outcome recorded
Phase 2/3	NCT02642601	Mar 2014 → Dec 2015	—	Cairo University	Unknown	No outcome recorded
Phase 2/3	NCT01912716	Jul 2013 → Apr 2018	pancreatitis	Indiana University	Completed	No outcome recorded
Phase 318 trials
Phase 3	NCT07599605	Mar → Dec 2024	pancreatitis	Hospital General de Chihuahua - Dr. Salvador Zubirán Anchondo	Completed	No outcome recorded
Phase 3	NCT05007522	May 2022 → Jun 2024	COVID-19	Sen-Jam Pharmaceutical	Completed	No outcome recorded
Phase 3	NCT03713879	Mar 2019 → Dec 2026 expected	pancreatitis	Chinese University of Hong Kong	Recruiting	No outcome recorded
Phase 3	NCT03662269	Oct 2018 → Aug 2020	respiratory system disorder	The First Affiliated Hospital of Guangzhou Medical University	Unknown	No outcome recorded
Phase 3	NCT03597867	Apr → Jul 2018	—	University of Trieste	Completed	No outcome recorded
Phase 3	NCT01360034	Dec 2015 → May 2016	obstetric disorder	Saint Thomas Hospital, Panama	Unknown	No outcome recorded
Phase 3	NCT02641561	Oct 2014 → Jun 2016	acute pancreatitis	The Cooper Health System	Completed	No outcome recorded
Phase 3	NCT02089425	Apr → Dec 2014	—	Kowa Research Institute, Inc.	Terminated	No outcome recorded
Phase 3	NCT02361645	Mar → Nov 2014	hyalitis	University of Brescia	Completed	No outcome recorded
Phase 3	NCT02110810	Jan 2014 → Jan 2015	acute pancreatitis	Mexican Social Security Institute	Completed	No outcome recorded
Phase 3	NCT01774604	Jan 2013 → Dec 2014	acute pancreatitis	Dartmouth-Hitchcock Medical Center	Terminated	No outcome recorded
Phase 3	NCT01626118	May → Aug 2012	—	Iroko Pharmaceuticals, LLC	Completed	No outcome recorded
Phase 3	NCT01543685	Feb → Jun 2012	—	Iroko Pharmaceuticals, LLC	Completed	No outcome recorded
Phase 3	NCT01265849	Dec 2010 → May 2020	carcinoma of soft palate, oral cavity squamous cell carcinoma	CEL-SCI Corporation	Completed	No outcome recorded
Phase 3	NCT00485160	Feb 2002 → Sep 2006	patent ductus arteriosus	Shaare Zedek Medical Center	Completed	No outcome recorded
Phase 3	NCT00432081	May 2000 → Aug 2005	Alzheimer disease	Radboud University Medical Center	Completed	No outcome recorded
Phase 3	NCT00009646	Nov 1993 → Mar 1999	patent ductus arteriosus, pulmonary immaturity	NICHD Neonatal Research Network	Completed	No outcome recorded
Phase 3	NCT00000494	Sep 1978 → Mar 1982	patent ductus arteriosus	National Heart, Lung, and Blood Institute (NHLBI)	Completed	No outcome recorded

Phase 420 trials
Phase 4	NCT07661498	Jul 2026 → Jul 2031 expected	acute pancreatitis	University of California, San Francisco	Not yet recruiting	No outcome recorded
Phase 4	NCT07536425	Apr 2026 → Oct 2027 expected	—	Western Galilee Hospital-Nahariya	Not yet recruiting	No outcome recorded
Phase 4	NCT07247682	Dec 2025 → Dec 2028 expected	pancreatitis	The First Affiliated Hospital of Anhui Medical University	Not yet recruiting	No outcome recorded
Phase 4	NCT03547232	Dec 2024 → Jun 2028 expected	acute pancreatitis, multiple organ dysfunction syndrome	Peking Union Medical College Hospital	Recruiting	No outcome recorded
Phase 4	NCT06253702	Jul 2024 → May 2025	cerebrovascular disorder	University of Wisconsin, Madison	Completed	No outcome recorded
Phase 4	NCT05664074	Nov 2022 → Feb 2025	acute pancreatitis	David Vitale MD	Completed	No outcome recorded
Phase 4	NCT02797067	May 2016 → Jul 2019	pancreatitis	Changhai Hospital	Completed	No outcome recorded
Phase 4	NCT02711358	Mar → Jul 2016	—	Assiut University	Completed	No outcome recorded
Phase 4	NCT03261635	Jan → Dec 2016	macular retinal edema	University of Brescia	Completed	No outcome recorded
Phase 4	NCT01957215	Oct 2013 → Sep 2014	—	GlaxoSmithKline	Completed	No outcome recorded
Phase 4	NCT01848665	May 2013 → Jun 2015	—	Brock University	Completed	No outcome recorded
Phase 4	NCT01830335	Apr 2013 → Jun 2015	neuromuscular disease	Brock University	Completed	No outcome recorded
Phase 4	NCT00904904	Apr 2008 → Jun 2009	cataract	Bausch & Lomb Incorporated	Completed	No outcome recorded
Phase 4	NCT00462111	Apr → Sep 2007	—	Sint Maartenskliniek	Completed	No outcome recorded
Phase 4	NCT00142558	Jan → May 2005	gout	Organon and Co	Completed	No outcome recorded
Phase 4	NCT00116623	Feb 2003 → Feb 2006	—	University of Pennsylvania	Terminated	No outcome recorded
Phase 4	NCT00554476	Jan 2003 → Apr 2006	epicondylitis	Azad University of Medical Sciences	Terminated	No outcome recorded
Phase 4	NCT00226122	Jan 2003 → Dec 2009	enuresis	University of Aarhus	Completed	No outcome recorded
Phase 4	NCT01073670	Aug 2000 → Apr 2002	hemorrhagic disease	Queen's University	Completed	No outcome recorded
Phase 4	NCT00473980	Dec 1998 → May 2007	colorectal cancer	Göteborg University	Completed	No outcome recorded

Phase not applicable10 trials
—	NCT07071441	Jun 2025 → Dec 2026 expected	pancreatitis	Air Force Military Medical University, China	Recruiting	No outcome recorded
—	NCT05637281	Dec 2022 → Dec 2023	acute pancreatitis, autoinflammatory syndrome	Second Affiliated Hospital, School of Medicine, Zhejiang University	Unknown	No outcome recorded
—	NCT06031363	Nov 2022 → Dec 2023	pancreatitis	The First Affiliated Hospital of Soochow University	Completed	No outcome recorded
—	NCT05109143	Oct 2020 → Apr 2022	—	Institute of Liver and Biliary Sciences, India	Completed	No outcome recorded
—	NCT03643900	Aug 2018 → Aug 2021	acute necrotizing pancreatitis	First People's Hospital of Hangzhou	Completed	No outcome recorded
—	NCT02002650	Dec 2013 → Nov 2015	acute pancreatitis	Air Force Military Medical University, China	Completed	No outcome recorded
—	NCT01744314	Nov 2012 → Nov 2019	—	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	Unknown	No outcome recorded
—	NCT01114516	Mar 2010 → Mar 2013	cervical incompetence	Northwestern University	Completed	No outcome recorded
—	NCT00727740	Aug 2005 → Aug 2011	pancreatitis	Yale University	Completed	No outcome recorded
—	NCT00239512	Mar 2005 → Jun 2006	patent ductus arteriosus	China Medical University Hospital	Terminated	No outcome recorded

Also used as a comparator or background therapy in 68 trials

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT05538247 Background	Apr 2023 → Dec 2025	—	Mayo Clinic	Completed	No outcome recorded
Phase 0	NCT01869361 Comparator	Aug 2020 → Nov 2021	—	MetroHealth Medical Center	Withdrawn	No outcome recorded
Phase 18 trials
Phase 1	NCT05999708 Background	Oct 2023 → Dec 2024	ulcerative colitis	GlaxoSmithKline	Withdrawn	No outcome recorded
Phase 1	NCT05035407 Background	Mar 2022 → Jul 2025	—	National Cancer Institute (NCI)	Terminated	No outcome recorded
Phase 1	NCT03712241 Comparator	Oct 2018 → Jan 2019	—	Kowa Research Institute, Inc.	Completed	No outcome recorded
Phase 1	NCT03648437 Background	Sep 2018 → Oct 2024	patent ductus arteriosus	University of Oulu	Terminated	No outcome recorded
Phase 1	NCT02950259 Background	Feb 2017 → May 2019	triple-negative breast carcinoma	Providence Health & Services	Completed	No outcome recorded
Phase 1	NCT02603822 Background	Aug 2015 → Jul 2018	disorder of metabolite absorption and transport	Mayo Clinic	Completed	No outcome recorded
Phase 1	NCT01884272 Comparator	Jun → Aug 2013	gout	Ardea Biosciences, Inc.	Completed	No outcome recorded
Phase 1	NCT01733485 Comparator	Oct 2011 → Sep 2016	asthma	Sally E. Wenzel MD	Completed	No outcome recorded

Phase 1/23 trials
Phase 1/2	NCT02858310 Background	Jan 2017 → Jul 2025	cervical intraepithelial neoplasia, human papilloma virus infection, in situ carcinoma, vulvar neoplasm	National Cancer Institute (NCI)	Completed	No outcome recorded
Phase 1/2	NCT00486824 Comparator	Apr 2007 → Dec 2012	obstetric disorder	Stanford University	Completed	No outcome recorded
Phase 1/2	NCT00002796 Background	May 1997 → Dec 2004	colon mucinous adenocarcinoma, colon signet ring cell adenocarcinoma, rectal signet ring cell adenocarcinoma, rectum mucinous adenocarcinoma	National Cancer Institute (NCI)	Terminated	No outcome recorded
Phase 26 trials
Phase 2	NCT06623513 Comparator	Oct 2024 → Sep 2026 expected	acute pancreatitis	Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine	Not yet recruiting	No outcome recorded
Phase 2	NCT03267680 Background	Nov 2017 → Aug 2023	uterine cervix carcinoma in situ, vulvar intraepithelial neoplasia	University of Southern California	Terminated	No outcome recorded
Phase 2	NCT02609386 Background	Jan 2016 → Feb 2022	oral cavity squamous cell carcinoma	Brooklyn ImmunoTherapeutics, LLC	Completed	No outcome recorded
Phase 2	NCT02602054 Comparator	Oct 2015 → Apr 2016	patent ductus arteriosus	Hospital General Naval de Alta Especialidad - Escuela Medico Naval	Unknown	No outcome recorded
Phase 2	NCT00997581 Comparator	Apr → Dec 2010	gout	Dartmouth-Hitchcock Medical Center	Withdrawn	No outcome recorded
Phase 2	NCT00210470 Background	Jul 2005 → Dec 2010	head and neck squamous cell carcinoma	Brooklyn ImmunoTherapeutics, LLC	Completed	No outcome recorded

Phase 2/32 trials
Phase 2/3	NCT03629600 Comparator	Oct 2017 → Feb 2018	acute pancreatitis	Post Graduate Institute of Medical Education and Research, Chandigarh	Completed	No outcome recorded
Phase 2/3	NCT00750581 Comparator	Aug 2008 → Jan 2013	patent ductus arteriosus	University of Calgary	Terminated	No outcome recorded
Phase 310 trials
Phase 3	NCT05252754 Background	Jan 2023 → Dec 2026 expected	acute pancreatitis	Johns Hopkins University	Recruiting	No outcome recorded
Phase 3	NCT05381428 Comparator	May 2022 → Oct 2024	acute pancreatitis	Azienda USL Reggio Emilia - IRCCS	Completed	No outcome recorded
Phase 3	NCT03533803 Comparator	Jun → Dec 2018	—	Cairo University	Completed	No outcome recorded
Phase 3	NCT03537144 Comparator	Jun 2016 → Sep 2018	patent ductus arteriosus	University of Tennessee	Terminated	No outcome recorded
Phase 3	NCT02692391 Comparator	Jul 2013 → Jul 2019	acute pancreatitis	University of Pittsburgh	Completed	No outcome recorded
Phase 3	NCT01742689 Background	Mar 2012 → Mar 2013	urinary tract obstruction	Tehran University of Medical Sciences	Unknown	No outcome recorded
Phase 3	NCT00855920 Comparator	Mar 2009 → Feb 2010	gout	Regeneron Pharmaceuticals	Completed	No outcome recorded
Phase 3	NCT00549549 Comparator	Feb 2008 → Dec 2009	gout	Viatris Inc.	Completed	No outcome recorded
Phase 3	NCT02183168 Comparator	Jul 2001 → May 2002	ankylosing spondylitis	Boehringer Ingelheim	Completed	No outcome recorded
Phase 3	NCT00033917 Comparator	Sep 1989 → Mar 2012	intracerebral hemorrhage	Yale University	Completed	No outcome recorded

Phase 418 trials
Phase 4	NCT07088757 Comparator	Sep 2025 → Nov 2026 expected	pancreatitis	Changhai Hospital	Recruiting	No outcome recorded
Phase 4	NCT06433453 Background	Apr → Dec 2024	anovulation	University of Saskatchewan	Unknown	No outcome recorded
Phase 4	NCT07037888 Background	Dec 2023 → Sep 2026 expected	—	Henry Ford Health System	Recruiting	No outcome recorded
Phase 4	NCT07173179 Comparator	Jan 2023 → Mar 2025	acute pancreatitis	Duzce University	Completed	No outcome recorded
Phase 4	NCT05132829 Background	Dec 2021 → Dec 2024	cervical incompetence, pregnancy disorder	Thomas Jefferson University	Unknown	No outcome recorded
Phase 4	NCT04410536 Background	Jun 2020 → Dec 2021	migraine disorder	Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta	Completed	No outcome recorded
Phase 4	NCT03473665 Comparator	Mar 2018 → Aug 2019	ankylosing spondylitis	Columbia University	Terminated	No outcome recorded
Phase 4	NCT03708458 Comparator	Apr 2017 → Dec 2018	pancreatitis	Grigore T. Popa University of Medicine and Pharmacy	Unknown	No outcome recorded
Phase 4	NCT02964403 Comparator	Dec 2016 → Feb 2018	acute pancreatitis	First Affiliated Hospital Xi'an Jiaotong University	Unknown	No outcome recorded
Phase 4	NCT02947932 Comparator	Dec 2016 → Mar 2018	acute pancreatitis	First Affiliated Hospital Xi'an Jiaotong University	Unknown	No outcome recorded
Phase 4	NCT02770950 Comparator	May 2016 → Jun 2017	osteoarthritis	Guang'anmen Hospital of China Academy of Chinese Medical Sciences	Completed	No outcome recorded
Phase 4	NCT03582332 Comparator	Jan → Jun 2016	spondyloarthropathy	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Completed	No outcome recorded
Phase 4	NCT02577809 Comparator	Jul → Sep 2015	—	University of Witwatersrand, South Africa	Completed	No outcome recorded
Phase 4	NCT02438371 Comparator	May 2015 → Oct 2019	—	The University of Texas Health Science Center, Houston	Terminated	No outcome recorded
Phase 4	NCT02111707 Comparator	Apr 2014 → Sep 2017	acute pancreatitis	University of Alberta	Completed	No outcome recorded
Phase 4	NCT00820612 Comparator	Jan 2009 → Jul 2011	pancreatitis	University of Michigan	Terminated	No outcome recorded
Phase 4	NCT00470743 Comparator	May 2007 → Jun 2009	patent ductus arteriosus	KK Women's and Children's Hospital	Withdrawn	No outcome recorded
Phase 4	NCT02183155 Comparator	May → Sep 2000	—	Boehringer Ingelheim	Completed	No outcome recorded

Phase not applicable19 trials
—	NCT06837831 Background	Feb 2026 → Jul 2027 expected	anus disorder, radiodermatitis, rectal cancer	Qianfoshan Hospital	Recruiting	No outcome recorded
—	NCT07495111 Background	Dec 2025 → Jun 2028 expected	choledocholithiasis	Qilu Hospital of Shandong University	Recruiting	No outcome recorded
—	NCT07117318 Background	Jul 2025 → Dec 2026 expected	acute pancreatitis	Air Force Military Medical University, China	Recruiting	No outcome recorded
—	NCT05947461 Comparator	Jun 2023 → Jun 2024	acute pancreatitis	Air Force Military Medical University, China	Terminated	No outcome recorded
—	NCT05857514 Comparator	May 2023 → May 2024	acute pancreatitis	Moti Lal Nehru Medical College	Unknown	No outcome recorded
—	NCT04726085 Comparator	Feb 2021 → Nov 2023	—	Woman's	Terminated	No outcome recorded
—	NCT04425993 Background	Jul 2020 → May 2022	acute pancreatitis	Air Force Military Medical University, China	Unknown	No outcome recorded
—	NCT04964180 Comparator	May 2020 → May 2021	—	South Valley University	Completed	No outcome recorded
—	NCT04145336 Background	Oct 2019 → Oct 2020	acute pancreatitis	Air Force Military Medical University, China	Unknown	No outcome recorded
—	NCT03620825 Comparator	Mar → Jun 2018	—	Örebro University, Sweden	Completed	No outcome recorded
—	NCT03057769 Background	Feb → Oct 2017	pancreatitis	Air Force Military Medical University, China	Terminated	No outcome recorded
—	NCT03129945 Comparator	Jan 2017 → Apr 2019	obstetric disorder	University of California, Irvine	Completed	No outcome recorded
—	NCT02884219 Comparator	Dec 2016 → Mar 2022	patent ductus arteriosus	Radboud University Medical Center	Completed	No outcome recorded
—	NCT02959112 Comparator	May 2016 → Jun 2019	acute pancreatitis	National Institute of Medical Sciences and Nutrition Salvador Zubiran	Terminated	No outcome recorded
—	NCT02368795 Comparator	Feb 2015 → Jan 2017	pancreatitis	Tehran University of Medical Sciences	Unknown	No outcome recorded
—	NCT02116309 Comparator	Aug 2014 → Dec 2016	acute pancreatitis	Johns Hopkins University	Completed	No outcome recorded
—	NCT01638962 Comparator	Aug 2012 → Aug 2015	osteoarthritis, knee	University of Southern Denmark	Completed	No outcome recorded
—	NCT00478335 Background	May 2007 → Oct 2012	nephrogenic diabetes insipidus	University of Colorado, Denver	Completed	No outcome recorded
—	NCT00811057 Comparator	Jun 2004 → Jun 2009	—	University of Mississippi Medical Center	Completed	No outcome recorded

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 155 sources stand behind the page.

Field	Value	Cited text
Known as	Indomethacin	“IV indomethacin 2 mg/kg/dose for three doses at 12 hour intervals; or IV Ibuprofen 10 mg/kg infused over 15 minutes, followed by two doses of 5mg/kg each at 24 hour intervals...” NCT01291654 ↗ 144 “The role of prostaglandin E2 is the permeability of the conduit, by which is indicated the use of cyclooxygenase inhibitors for closure (indomethacin and ibuprofen).” NCT02602054 ↗ “All patients without contraindications should receive 100mg rectal indomethacin or diclofenac within 30mins before ERCP procedure” NCT07117318 ↗ “Indomethacin 5 MG/ML Ophthalmic Suspension, "Indom ®", NSAID eyedrops administered three days before surgery” NCT03597867 ↗ “Those randomized to rectal Indomethacin received only per-rectal 100 mg suppository immediately post-ERCP.” PMID 35470300 ↗ Apr 2022 “A 30 mg indomethacin suppository was administered rectally 30 minutes before dressing placement.” NCT06837831 ↗ “Indomethacin, ibuprofen or acetaminophen will be used as standard of care treatment” NCT01958320 ↗ “indomethacin 75mg 1 tablet QD to start on POD0 10 tablets” NCT07037888 ↗ “additional reservoir containing indomethacin (IND)” PMID 36648744 ↗ Jan 2023 “indomethacin suppository 50-100 mg” NCT04410536 ↗ “K-103-IP: 0.5% indomethacin” NCT02089425 ↗ “Indomethacin” NCT01638962 ↗ NCT02653638 ↗ NCT01577121 ↗ NCT01774604 ↗ NCT02577809 ↗ NCT00858195 ↗ NCT04207060 ↗ NCT06031363 ↗ NCT02111707 ↗ NCT02609386 ↗ NCT00009646 ↗ NCT04145336 ↗ NCT00904904 ↗ NCT01848665 ↗ NCT02205762 ↗ NCT00262470 ↗ NCT02641561 ↗ NCT02950259 ↗ NCT03662269 ↗ NCT00466128 ↗ NCT00033917 ↗ NCT01733485 ↗ NCT00820612 ↗ NCT00142558 ↗ NCT00000494 ↗ NCT02002650 ↗ NCT04265053 ↗ NCT05857514 ↗ NCT02849990 ↗ NCT02183168 ↗ NCT01912716 ↗ NCT04404686 ↗ NCT05664074 ↗ NCT03057769 ↗ NCT01360034 ↗ NCT05132829 ↗ NCT05999708 ↗ NCT01265849 ↗ NCT00226122 ↗ NCT06623513 ↗ NCT05722548 ↗ NCT00964431 ↗ NCT04726085 ↗ NCT05947461 ↗ NCT03712241 ↗ NCT02964403 ↗ NCT04025177 ↗ NCT01830335 ↗ NCT00432081 ↗ NCT02361645 ↗ NCT00997581 ↗ NCT01957215 ↗ NCT00485160 ↗ NCT00811057 ↗ NCT02947932 ↗ NCT00002796 ↗ NCT01543685 ↗ NCT04344457 ↗ NCT02221219 ↗ NCT02858310 ↗ NCT05381428 ↗ NCT02959112 ↗ NCT00473980 ↗ NCT00616382 ↗ NCT01070745 ↗ NCT03547232 ↗ NCT00478335 ↗ NCT00210470 ↗ NCT07661498 ↗ NCT01114516 ↗ NCT00554476 ↗ NCT03582332 ↗ NCT00239512 ↗ NCT01742689 ↗ NCT07088757 ↗ NCT01626118 ↗ NCT03643900 ↗ NCT07173179 ↗ NCT06433453 ↗ NCT02797067 ↗ NCT02642601 ↗ NCT01884272 ↗ NCT00116623 ↗ NCT02884219 ↗ NCT01869361 ↗ NCT00187447 ↗ NCT03537144 ↗ NCT02438371 ↗ NCT00470743 ↗ NCT03620825 ↗ NCT00549549 ↗ NCT06253702 ↗ NCT04425993 ↗ NCT00002535 ↗ NCT05007522 ↗ NCT03708458 ↗ NCT02110810 ↗ NCT01280006 ↗ NCT07536425 ↗ NCT02711358 ↗ NCT04964180 ↗ NCT01073670 ↗ NCT02935205 ↗ NCT07218653 ↗ NCT03261635 ↗ NCT02692391 ↗ NCT07071441 ↗ NCT02603822 ↗ NCT07495111 ↗ NCT02183155 ↗ NCT06572917 ↗ NCT00486824 ↗ NCT05252754 ↗ NCT00722033 ↗ NCT05035407 ↗ NCT00223691 ↗ NCT03473665 ↗ NCT05109143 ↗ NCT01719926 ↗ NCT03533803 ↗ NCT03648437 ↗ NCT03129945 ↗ NCT00855920 ↗ NCT04821323 ↗ NCT03713879 ↗ NCT05538247 ↗ NCT00750581 ↗ NCT01744314 ↗ NCT03267680 ↗ NCT07560566 ↗ NCT02116309 ↗ NCT02368795 ↗ NCT02633969 ↗ NCT00727740 ↗
Known as	CHRONO-INDOCID	ClinicalTrials.gov intervention name — accepted as the source's own label NCT03985969 ↗
Known as	Extended-release indomethacin	“Extended-release indomethacin capsules (75 mg) was an active control to assess trial sensitivity on bleeding time in healthy subjects.” NCT02183155 ↗
Known as	IND	“additional reservoir containing indomethacin (IND)” PMID 36648744 ↗ Jan 2023
Known as	INDO	“However, Indomethacin (INDO) can be prescribed for medical ductal closure if this is preferred by a participating center.” NCT02884219 ↗
Known as	Indom	“Indomethacin 5 MG/ML Ophthalmic Suspension, "Indom ®", NSAID eyedrops administered three days before surgery” NCT03597867 ↗
Known as	indometacin	“Although rectal indometacin 100 mg is effective in reducing the frequency and severity of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) in high-risk patients” PMID 31780277 ↗ Nov 2019 8 “administration of 100 mg rectal indometacin immediately after ERCP” NCT07247682 ↗ “75mg/day indometacin (Chronoindocid®)” NCT01146197 ↗ “Drug: Rectal Form Indometacin” NCT03629600 ↗ NCT07599605 ↗ NCT05637281 ↗ NCT02770950 ↗ NCT00943345 ↗ NCT00462111 ↗
Known as	Indomethacin 5 MG/ML Ophthalmic Suspension	“Indomethacin 5 MG/ML Ophthalmic Suspension” NCT03597867 ↗
Action	Inhibit	“the use of indomethacin, a prostaglandin inhibitor, may decrease prostaglandin synthesis” NCT00466128 ↗
Modality	Small molecule	“non-steroidal antiinflammatory drug” NCT00820612 ↗
Route	Oral	“Given orally” NCT00002796 ↗