drugset / Trial / NCT00485160

Ibuprofen vs. Continuous Indomethacin in the Treatment of PDA

NCT00485160

Phase 3 Completed 70 enrolled Shaare Zedek Medical Center
RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine whether closure of the PDA in premature neonates using IV ibuprofen vs continuous IV indomethacin has different side effects, eg. effects on renal function, on blood flow velocity in the superior mesenteric artery, the anterior cerebral artery, and the renal artery.

Timeline

Start
2002-02
Primary completion
Completion
2006-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Ibuprofen Small molecule Intravenous
Subject Indomethacin Small molecule Intravenous