Nifedipine or Nifedipine Plus Indomethacin for Treatment of Acute Preterm Labor

Phase 4 Terminated 49 enrolled The University of Texas Health Science Center, Houston

RandomizedParallel-groupOpen-labelTreatment

Summary

Tocolytic agents are used for the treatment of preterm labor. It is unclear whether combination treatments of two tocolytic agents are more effective in stopping preterm labor compared to one. Therefore, the investigators propose a comparative effective trial of nifedipine plus indomethacin vs. nifedipine alone for the treatment of preterm labor

Timeline

Start: 2015-05
Primary completion: 2019-10-10
Completion: 2019-10-10

Publications

Wilson A, Hodgetts-Morton VA, Marson EJ, Markland AD, Larkai E, Papadopoulou A, Coomarasamy A, Tobias A, Chou D, Oladapo OT, Price MJ, Morris K, Gallos ID. Tocolytics for delaying preterm birth: a network meta-analysis (0924). Cochrane Database Syst Rev. 2022 Aug 10;8(8):CD014978. doi: 10.1002/14651858.CD014978.pub2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Indomethacin	Small molecule	50 mg	Oral
Comparator	Nifedipine	Other / unclassified	10 mg	Oral

Indications

No indication recorded.