drugset / Trial / NCT00002796
Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
NaSingle-groupOpen-labelTreatment
Summary
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor cells. This phase I/II trial is studying the side effects and best dose of giving fluorouracil together with phenylbutyrate, indomethacin, and interferon-gamma and to see how well it works in treating patients with stage IV colorectal cancer
Timeline
- Start
- 1997-05
- Primary completion
- 2004-12
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | fluorouracil | Small molecule | — | Intravenous |
| Background | Indomethacin | Small molecule | — | Oral |
| Background | Interferon gamma-1b | Protein / enzyme biologic | — | Subcutaneous |
| Background | Sodium Phenylbutyrate | Small molecule | — | Intravenous |