Intrathecal Opioid Study

Phase 4 Completed 100 enrolled University of Witwatersrand, South Africa

RandomizedParallel-groupDouble-blindTreatment

Summary

This is an interventional drug trail to evaluate the effect of different intrathecal opioids on post-operative pain experiences in women who have undergone caesarean section surgery.

Timeline

Start: 2015-07
Primary completion: 2015-09
Completion: 2015-09

Publications

Chetty S, Paruk F, Kamerman P. Low-dose intrathecal morphine versus intrathecal fentanyl for post-caesarean analgesia in a resource-constrained setting: a pragmatic randomised trial. BMC Anesthesiol. 2026 Jun 23. doi: 10.1186/s12871-026-04034-0. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Fentanyl	Other / unclassified	25 ug	Intrathecal
Comparator	Morphine	Other / unclassified	50 ug	Intrathecal
Comparator	Morphine	Other / unclassified	100 ug	Intrathecal
Comparator	Bupivacaine	Other / unclassified	0.5 %	Intrathecal
Comparator	Bupivacaine	Other / unclassified	1.8 ml	Intrathecal
Comparator	Indomethacin	Small molecule	100 mg	Rectal

Indications

No indication recorded.