Bupivacaine Alone vs Bupivacaine With Tramadol in Local Anesthesia Procedures

Summary

This study looked at two different medicines used during local anesthesia to control pain after surgery. Investigators compared bupivacaine alone with bupivacaine mixed with tramadol. Both medicines are commonly used to numb the surgical area and reduce pain. The investigators included 100 adult patients who had minor surgeries under local anesthesia. Half received only bupivacaine, and the other half received bupivacaine combined with tramadol. After surgery, patients were asked to rate their pain at 4, 8, and 24 hours. The results showed that patients who received bupivacaine with tramadol felt less pain, especially at 24 hours after surgery, compared to those who received bupivacaine alone. In simple words: Adding tramadol to bupivacaine helps reduce pain better than bupivacaine alone. This method may help patients recover faster, feel more comfortable, and need fewer pain medicines after surgery.

Timeline

Start

2022-10-10

Primary completion

2023-04-10

Completion

2023-05-10

Publications

• Background Malik AI, Sheikh IA, Qasmi SA, Adnan A. Comparison of tramadol with bupivacaine as local anaesthetic in postoperative pain control. Journal of Surgery Pakistan (International). 2011 Jan;16(1):10-3.
• Background Khan S, Memon MI. Comparison of caudal bupivacaine and bupivacaine-tramadol for postoperative analgesia in children with hypospadias repair. J Coll Physicians Surg Pak. 2008 Oct;18(10):601-4. doi: 10.2008/JCPSP.601604.
• Background Passavanti MB, Piccinno G, Alfieri A, Di Franco S, Sansone P, Mangoni G, Pota V, Aurilio C, Pace MC, Fiore M. Local infiltration of tramadol as an effective strategy to reduce post-operative pain: a systematic review protocol and meta-analysis. Syst Rev. 2020 Jul 13;9(1):157. doi: 10.1186/s13643-020-01419-1.
• Background Kelley BP, Shauver MJ, Chung KC. Management of Acute Postoperative Pain in Hand Surgery: A Systematic Review. J Hand Surg Am. 2015 Aug;40(8):1610-9, 1619.e1. doi: 10.1016/j.jhsa.2015.05.024.
• Background Obsa MS, Andebirku AA, Gemechu AD, Haile KE. Effectiveness of tramadol with bupivacaine versus bupivacaine alone on postoperative analgesia at Wolaita Sodo, southern Ethiopia: Observational Cohort Study. 2021
• Background Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, Carter T, Cassidy CL, Chittenden EH, Degenhardt E, Griffith S, Manworren R, McCarberg B, Montgomery R, Murphy J, Perkal MF, Suresh S, Sluka K, Strassels S, Thirlby R, Viscusi E, Walco GA, Warner L, Weisman SJ, Wu CL. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016 Feb;17(2):131-57. doi: 10.1016/j.jpain.2015.12.008.
• Background Jenkins NW, Parrish JM, Mayo BC, Hrynewycz NM, Brundage TS, Mogilevsky FA, Yoo JS, Singh K. The identification of risk factors for increased postoperative pain following minimally invasive transforaminal lumbar interbody fusion. Eur Spine J. 2020 Jun;29(6):1304-1310. doi: 10.1007/s00586-020-06344-4. Epub 2020 Feb 19.
• Background Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017 Sep 25;10:2287-2298. doi: 10.2147/JPR.S144066. eCollection 2017.
• Background Kuusniemi K, Poyhia R. Present-day challenges and future solutions in postoperative pain management: results from PainForum 2014. J Pain Res. 2016 Feb 3;9:25-36. doi: 10.2147/JPR.S92502. eCollection 2016.
• Background Labrum JT 4th, Ilyas AM. Preemptive Analgesia in Thumb Basal Joint Arthroplasty: Immediate Postoperative Pain with Preincision versus Postincision Local Anesthesia. J Hand Microsurg. 2017 Aug;9(2):80-83. doi: 10.1055/s-0037-1603734. Epub 2017 Jun 5.

Drugs

Indications

No indication recorded.