drugset / Trial / NCT02750696
Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess
Completed
27 enrolled
Federal University of Rio Grande do Sul
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
Aim: The aim of this study was to compare the analgesic efficacy of two combinations of opioid and non-opioid analgesics for acute periradicular abscesses. Methodology: This study included 24 patients who sought emergency care in a Brazilian dental school. The patients were randomly divided into two groups: Codeine/Acetaminophen - oral prescription of codeine (30 mg) plus acetaminophen (500 mg), every 4 h, for 3 days or Tramadol/Acetaminophen - oral prescription of tramadol hydrochloride (37.5 mg) plus acetaminophen (500 mg) on the same schedule. Patients recorded pain scores in a pain diary 6, 12, 24, 48, and 72 h after treatment, using the Visual Analogue Scale.
Timeline
- Start
- 2013-04
- Primary completion
- 2014-12
- Completion
- 2015-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 325 mg | Oral |
| Subject | Acetaminophen | Small molecule | 500 mg | Oral |
| Comparator | Codeine | Small molecule | 30 mg | Oral |
| Subject | Tramadol | Other / unclassified | 37.5 mg | Oral |