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drugset / Trial / NCT05626140

COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA

NCT05626140 ↗

Phase 3 Completed 120 enrolled Pakistan Institute of Medical Sciences Riphah International University · collab
Non-randomizedParallel-groupSingle-blindTreatment

Summary

The goal of this clinical trial is to compare different combinations of diclofenac with diclofenac monotherapy in acute sciatica. The main questions it aims to answer are: * Does the combination of diclofenac plus codeine better than diclofenac monotherapy for treating severe pain of sciatica * Does the combination of diclofenac plus lacosamide better than diclofenac monotherapy for treating severe pain of sciatica Participants will be asked to mark their pain intensity on a visual analog scale and fill oswestry disabilit index questionnaire,treatments they'll be given includes either 1. Diclofenac monotherapy 2. Diclofenac plus codeine 3. Diclofenac plus lacosamide Researchers will compare the above three groups to see if severity of pain and disability lowered after medication

Timeline

Start
2021-09-28
Primary completion
2022-05-31
Completion
2022-07-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Codeine Small molecule 30 mg Oral
Subject Diclofenac Other / unclassified 50 mg Oral
Subject Lacosamide Other / unclassified 50 mg Oral

Indications

sciatica