drugset / Trial / NCT00105209
A Study of Aspirin and Clopidogrel in Patients With Idiopathic Pulmonary Arterial Hypertension
Phase 2
Completed
20 enrolled
Kawut, Steven, MD
Columbia University · collabNational Heart, Lung, and Blood Institute (NHLBI) · collab
RandomizedCrossoverDouble-blindTreatment
Summary
Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is characterized by in situ thrombosis and increased thromboxane A2 (Tx-M) synthesis. While both may be attributable to abnormal platelet function, there are no studies of anti-platelet therapy in IPAH. Objectives: The purpose of this study is to assess the effects of aspirin (ASA) and clopidogrel on platelet function and eicosanoid metabolism in patients with IPAH.
Timeline
- Start
- 2002-04
- Primary completion
- —
- Completion
- 2003-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aspirin | Small molecule | 81 mg | — |
| Subject | Clopidogrel | Small molecule | 75 mg | — |