drugset / Trial / NCT07673185
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
RandomizedParallel-groupQuadruple-blindTreatment
Summary
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment
Timeline
- Start
- 2025-01-15
- Primary completion
- 2026-07-30
- Completion
- 2026-10-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Aspirin | Small molecule | 75 mg | Oral |
| Subject | DHA | Other / unclassified | 480 mg | Oral |
| Subject | EPA | Other / unclassified | 640 mg | Oral |