drugset / Trial / NCT07673185

Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis

NCT07673185

Recruiting 40 enrolled Al-Azhar University
RandomizedParallel-groupQuadruple-blindTreatment

Summary

This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment

Timeline

Start
2025-01-15
Primary completion
2026-07-30
Completion
2026-10-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Aspirin Small molecule 75 mg Oral
Subject DHA Other / unclassified 480 mg Oral
Subject EPA Other / unclassified 640 mg Oral

Indications