Measurement of Platelet Dense Granule Release in Healthy Volunteers

Summary

Aspirin has been shown to reduce cardiovascular events in at risk individuals. Elucidation of mechanisms of aspirin resistance and a possible loss of effect of aspirin over time with chronic aspirin treatment necessitate a more precise method of measuring the "release phase" of platelet activation, including the release of dense granules from platelets.

Timeline

Start

2009-07

Primary completion

2012-06

Completion

2012-06

Drugs

Indications