Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma

Summary

This phase IIa trial studies how well aspirin works in preventing colorectal cancer in patients with colorectal adenoma. Aspirin may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Timeline

Start

2018-01-16

Primary completion

2023-01-31

Completion

2026-12-24

Publications

• Zhu X, Chen R, Ness RM, Naik RD, Murff HJ, Zhang H, Xu Y, Benante KA, Azcarate-Peril MA, Zheng Y, Wang J, Shrubsole MJ, Su T, Mi X, Kocherginsky M, Rodriguez LM, Della'Zanna G, Richmond E, Hou L, Khan SA, Dai Q. Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention. Cancer Prev Res (Phila). 2025 Jun 2;18(6):321-334. doi: 10.1158/1940-6207.CAPR-24-0168.

Drugs

Indications