Drugs / Donepezil
last change 3 days ago re-read 2 minutes ago

Donepezil

Small molecule targets ACHE via inhibition

Developed for
Alzheimer disease · Parkinson disease · cognitive impairment with or without cerebellar ataxia · cognitive disorder · dementia · Lewy body dementia · stroke disorder · vascular dementia
+40 more · delirium · radiation-induced disorder · autism · obstructive sleep apnea syndrome · alcohol-related disorders · amnestic disorder · anorexia nervosa · aphasia · autism spectrum disorder · Down syndrome · ischemic stroke · neuropathy, painful · Rett syndrome · schizophrenia · amblyopia · brain injury · chemotherapy-induced toxicity · cocaine dependence · fragile X syndrome · major depressive disorder · manic bipolar affective disorder · migraine disorder · multiple sclerosis · osteoporosis · progressive supranuclear palsy · relapsing-remitting multiple sclerosis · sensorineural hearing loss disorder · substance-related disorder · tinnitus · type 2 diabetes mellitus · acquired aneurysmal subarachnoid hemorrhage · brain ischemia · chronic pain syndrome · diabetic neuropathy · hypersomnia · intracranial vasospasm · schizoaffective disorder · schizophreniform disorder · traumatic brain injury · traumatic neuropathy
Investigated by
Eisai Inc. · Pfizer · Merck Sharp & Dohme LLC · National Institute of Mental Health (NIMH) · Eisai Co., Ltd. · National Cancer Institute (NCI)
+142 more · National Institute on Aging (NIA) · Corium, Inc. · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · New York State Psychiatric Institute · Oregon Health and Science University · Teva Pharmaceuticals USA · Wake Forest University Health Sciences · AstraZeneca · GlaxoSmithKline · Icure Pharmaceutical Inc. · Samsung Medical Center · Stanford University · São Paulo Research Foundation · University of Pittsburgh · Associacao Fundo de Incentivo a Psicofarmcologia · Boehringer Ingelheim · Chase Pharmaceuticals Corporation, an affiliate of Allergan plc · Chong Kun Dang Pharmaceutical · Dong-A ST Co., Ltd. · Dr. Reddy's Laboratories Limited · Duke University · French National Institute of Health and Medical Research · G2GBio, Inc. · National Institute of Neurological Disorders and Stroke (NINDS) · RenJi Hospital · Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Takeda · US Department of Veterans Affairs · University Hospital, Clermont-Ferrand · University of Maryland, Baltimore · University of Sao Paulo · VA Connecticut Healthcare System · Abramson Cancer Center at Penn Medicine · Agency for Healthcare Research and Quality (AHRQ) · Alliance for Clinical Trials in Oncology · Alzheimer's Disease Cooperative Study (ADCS) · Alzheimer's Society · Asan Medical Center · Assistance Publique - Hôpitaux de Paris · Bangor University · Beersheva Mental Health Center · Beijing Friendship Hospital · Boston Children's Hospital · Bristol-Myers Squibb · Centre Hospitalier St Anne · Chung-Ang University · Dong-A University · Dongkook Pharmaceutical Co., Ltd. · Duke-NUS Graduate Medical School · Eisai Deutschland · Eisai Inc. · Eli Lilly and Company · European Union · Ever Neuro Pharma GmbH · FORUM Pharmaceuticals Inc · Federation Francophone de Cancerologie Digestive · Filadelfia Epilepsy Hospital · France Alzheimer · Gabinete Berthier y Martínez · Groupe Hospitalier Pitie-Salpetriere · Hannover Medical School · Hebrew SeniorLife · Hyundai Pharm · Imperial College London · Indiana University · Indiana University Health · Inje University · Institute of Psychiatry, London · International Brain Research Foundation · International Stem Cell Forum · Inventage Lab., Inc. · Janssen-Cilag Farmaceutica Ltda. · Johns Hopkins University · all 148 on the full record

Regulatory milestones approvals, filings & regulatory actions · 3 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Refused (EMA) EU (EMA) Balaxur 2013-02-20 europa.eu
Label expansion US (FDA) ARICEPT ODT 2006-10-13 fda.gov
Approved US (FDA) ARICEPT 1996-11-25 fda.gov

Trials 191 · started per year

today
US approved 1996
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1995199619971998199920002001200220032004200520062007200820092010201120122013201420152016201720182019202020212022202320242025202620272028
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials
Phase 0 NCT05438264 Mar 2023 → Sep 2026 expected sensorineural hearing loss disorder Vanderbilt University Medical Center Active not recruiting No outcome recorded
Phase 0 NCT05540977 Aug 2022 → May 2023 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Unknown No outcome recorded
Phase 0 NCT03599726 Jul 2018 → May 2019 Parkinson disease Oregon Health and Science University Completed No outcome recorded
Phase 0 NCT00452868 Jun 2006 → Feb 2010 central nervous system neoplasm, chemotherapy-induced toxicity, cognitive disorder, radiation-induced disorder Wake Forest University Health Sciences Completed No outcome recorded
Phase 155 trials
Phase 1 NCT06373094 Jun 2024 → Mar 2025 Alzheimer disease Shanghai Synergy Pharmaceutical Sciences Co., Ltd. Unknown No outcome recorded
Phase 1 NCT06127368 Jan → Sep 2024 Alzheimer disease G2GBio, Inc. Unknown No outcome recorded
Phase 1 NCT05804279 Dec 2022 → Feb 2023 Hyundai Pharm Completed No outcome recorded
Phase 1 NCT05525780 Aug 2022 → Jun 2023 Alzheimer disease G2GBio, Inc. Completed No outcome recorded
Phase 1 NCT05136690 Apr → Sep 2022 schizophrenia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT05127746 Nov 2021 → Dec 2022 Dong-A ST Co., Ltd. Completed No outcome recorded
Phase 1 NCT04730635 Mar 2021 → Jan 2023 Alzheimer disease, cognitive impairment with or without cerebellar ataxia Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT04308304 Feb 2021 → May 2022 Alzheimer disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT04479865 Jul → Dec 2020 Dong-A ST Co., Ltd. Unknown No outcome recorded
Phase 1 NCT03740178 Sep 2019 → Feb 2020 Alzheimer disease, cognitive impairment with or without cerebellar ataxia Merck Sharp & Dohme LLC Withdrawn No outcome recorded
Phase 1/24 trials
Phase 1/2 NCT05345509 Apr 2023 → Nov 2025 overdue Alzheimer disease Inventage Lab., Inc. Active not recruiting No outcome recorded
Phase 1/2 NCT02696512 Mar 2016 → Mar 2017 brain injury International Brain Research Foundation Unknown No outcome recorded
Phase 1/2 NCT01442766 Nov 2011 → Nov 2013 stroke disorder Imperial College London Withdrawn No outcome recorded
Phase 1/2 NCT00695136 Jun 2008 → Jan 2011 autism, cognitive disorder National Institute of Mental Health (NIMH) Completed No outcome recorded
Phase 237 trials
Phase 2 NCT06518941 Jun 2026 → Jun 2027 expected anorexia nervosa New York State Psychiatric Institute Not yet recruiting No outcome recorded
Phase 2 NCT06041789 Feb 2025 → Nov 2026 expected osteoporosis Duke University Recruiting No outcome recorded
Phase 2 NCT06903910 Nov 2024 → Jun 2025 Parkinson disease University of Virginia Completed No outcome recorded
Phase 2 NCT06687993 Nov 2024 → Feb 2030 expected anorexia nervosa Centre Hospitalier St Anne Not yet recruiting No outcome recorded
Phase 2 NCT05709301 Oct 2023 → Nov 2025 Parkinson disease, cognitive impairment with or without cerebellar ataxia Sant Pau Research Institute Unknown No outcome recorded
Phase 2 NCT05042102 Aug 2022 → Oct 2026 expected alcohol-related disorders VA Connecticut Healthcare System Recruiting No outcome recorded
Phase 2 NCT05254639 Jun 2022 → Jan 2024 digestive system cancer University Hospital, Clermont-Ferrand Completed No outcome recorded
Phase 2 NCT04505670 Aug 2020 → Jul 2023 University of Maryland, Baltimore Unknown No outcome recorded
Phase 2 NCT04507438 Jul 2019 → Sep 2023 type 2 diabetes mellitus University of Maryland, Baltimore Terminated No outcome recorded
Phase 2 NCT03907371 May 2019 → Dec 2022 cognitive disorder, radiation-induced disorder Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Unknown No outcome recorded
Phase 2/33 trials
Phase 2/3 NCT04318639 Aug 2018 → Dec 2019 alcohol-related disorders, cognitive impairment with or without cerebellar ataxia VA Connecticut Healthcare System Completed No outcome recorded
Phase 2/3 NCT03090516 Aug 2016 → Mar 2020 Alzheimer disease The First Affiliated Hospital with Nanjing Medical University Unknown No outcome recorded
Phase 2/3 NCT02248636 Jan 2015 → Oct 2019 dementia VA Office of Research and Development Completed No outcome recorded
Phase 326 trials
Phase 3 NCT04661280 Feb 2022 → Aug 2026 overdue Assistance Publique - Hôpitaux de Paris Recruiting No outcome recorded
Phase 3 NCT04134416 Jan 2019 → Oct 2020 aphasia, stroke disorder University of Malaga Completed No outcome recorded
Phase 3 NCT02927522 Sep 2018 → Dec 2021 avascular necrosis, osteoarthritis, rheumatoid arthritis RenJi Hospital Unknown No outcome recorded
Phase 3 NCT03197740 Oct 2017 → Jul 2020 Alzheimer disease Icure Pharmaceutical Inc. Completed No outcome recorded
Phase 3 NCT02374567 Jan 2015 → Jun 2017 anxiety disorder, dementia, depressive disorder, schizophrenia +1 Hannover Medical School Terminated No outcome recorded
Phase 3 NCT02550665 Dec 2014 → Aug 2016 Alzheimer disease Asan Medical Center Completed No outcome recorded
Phase 3 NCT01014858 Jan 2013 → Sep 2014 Parkinson disease Newcastle-upon-Tyne Hospitals NHS Trust Terminated No outcome recorded
Phase 3 NCT01404169 Sep 2011 → Jul 2014 Alzheimer disease Eisai Inc. Completed No outcome recorded
Phase 3 NCT01278407 Feb 2011 → Mar 2013 Lewy body dementia Eisai Inc. Completed No outcome recorded
Phase 3 NCT00868010 Mar 2009 → Aug 2013 ischemic stroke Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Unknown No outcome recorded
Phase 447 trials
Phase 4 NCT03454646 Jun 2024 → Apr 2027 expected Alzheimer disease University Hospital, Bordeaux Not yet recruiting No outcome recorded
Phase 4 NCT07153991 Nov 2021 → Dec 2025 overdue tinnitus University of Sao Paulo Active not recruiting No outcome recorded
Phase 4 NCT04423276 Jun 2020 → Dec 2021 vertebral column disorder RenJi Hospital Unknown No outcome recorded
Phase 4 NCT04117178 Feb 2020 → Feb 2023 Alzheimer disease, Lewy body dementia, Parkinson disease Zealand University Hospital Completed No outcome recorded
Phase 4 NCT02787746 Apr 2016 → Jan 2019 Alzheimer disease Beijing Friendship Hospital Completed No outcome recorded
Phase 4 NCT02345213 Mar 2015 → May 2017 Lewy body dementia Eisai Inc. Completed No outcome recorded
Phase 4 NCT02264353 Sep 2014 → May 2015 obstructive sleep apnea syndrome University of California, San Diego Completed No outcome recorded
Phase 4 NCT02097056 Feb 2014 → May 2015 Alzheimer disease Eisai Co., Ltd. Completed No outcome recorded
Phase 4 NCT01951118 Oct 2013 → May 2019 Alzheimer disease, cognitive impairment with or without cerebellar ataxia New York State Psychiatric Institute Completed No outcome recorded
Phase 4 NCT02660983 Aug 2013 → Jul 2018 vascular dementia Eisai Inc. Completed No outcome recorded
Phase not applicable15 trials
NCT07680660 Jul 2026 → Sep 2028 expected Alzheimer disease Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Not yet recruiting No outcome recorded
NCT05641480 Jun 2022 → Dec 2025 Alzheimer disease, cognitive impairment with or without cerebellar ataxia, subjective cognitive decline Shaanxi Hospital of Traditional Chinese Medicine Unknown No outcome recorded
NCT01362686 Apr 2011 → Oct 2015 Alzheimer disease Indiana University Terminated No outcome recorded
NCT01082965 Jul 2010 → Jul 2012 Alzheimer disease Pfizer Terminated No outcome recorded
NCT00934531 Sep 2009 → Jan 2019 cognitive impairment with or without cerebellar ataxia London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Completed No outcome recorded
NCT00776347 Oct 2008 → Feb 2015 Lewy body dementia Osaka University Completed No outcome recorded
NCT01379001 Jul 2008 → Jan 2013 Hebrew SeniorLife Completed No outcome recorded
NCT01023425 Feb 2008 → Apr 2009 Alzheimer disease Samsung Medical Center Completed No outcome recorded
NCT00533065 Sep 2007 → Jul 2009 Ludwig Boltzmann Gesellschaft Completed No outcome recorded
NCT01023867 Mar 2007 → Jun 2010 Alzheimer disease Samsung Medical Center Completed No outcome recorded
Also used as a comparator or background therapy in 96 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 04 trials
Phase 0 NCT07208344 Background Jul → Dec 2025 overdue Alzheimer disease Anhui Provincial Hospital Recruiting No outcome recorded
Phase 0 NCT06393413 Comparator Dec 2022 → Dec 2023 Changchun University of Chinese Medicine Completed No outcome recorded
Phase 0 NCT05003063 Comparator Feb → Aug 2021 University of California, Berkeley Completed No outcome recorded
Phase 0 NCT01024660 Comparator Dec 2009 → Jan 2011 Alzheimer disease AstraZeneca Completed No outcome recorded
Phase 114 trials
Phase 1 NCT06774261 Comparator Feb → Dec 2025 Alzheimer disease, cognitive impairment with or without cerebellar ataxia Helse Stavanger HF Completed No outcome recorded
Phase 1 NCT07094438 Comparator Jan 2025 → Jun 2026 overdue Alzheimer disease Chinese PLA General Hospital Recruiting No outcome recorded
Phase 1 NCT06285240 Background Mar → Sep 2024 Alzheimer disease Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT04617782 Comparator Dec 2020 → Apr 2021 Corium, Inc. Completed No outcome recorded
Phase 1 NCT03932916 Comparator Jul 2019 → Aug 2020 Shanghai Synergy Pharmaceutical Sciences Co., Ltd. Completed No outcome recorded
Phase 231 trials
Phase 2 NCT05538507 Comparator Jun 2022 → Jun 2024 Alzheimer disease, cognitive impairment with or without cerebellar ataxia Peking Union Medical College Hospital Unknown No outcome recorded
Phase 2 NCT02305836 Comparator Jun 2017 → Jun 2019 cognitive disorder Guang'anmen Hospital of China Academy of Chinese Medical Sciences Unknown No outcome recorded
Phase 2 NCT03055741 Background Dec 2016 → Feb 2019 Alzheimer disease Daehwa Pharmaceutical Co., Ltd. Completed No outcome recorded
Phase 2 NCT01255046 Comparator Dec 2015 → Dec 2018 Alzheimer disease Sinphar Pharmaceutical Co., Ltd Unknown No outcome recorded
Phase 2 NCT02580305 Comparator Sep 2015 → Nov 2019 Alzheimer disease Suven Life Sciences Limited Completed No outcome recorded
Phase 2/32 trials
Phase 2/3 NCT07066826 Comparator Aug 2025 → Aug 2028 expected Alzheimer disease Wanbangde Pharmaceutical Group Co., LTD Not yet recruiting No outcome recorded
Phase 2/3 NCT05811000 Comparator Nov 2020 → Feb 2021 Alzheimer disease Mediforum Ltd., Co. Unknown No outcome recorded
Phase 315 trials
Phase 3 NCT05564169 Background Jun 2026 → Dec 2028 expected Alzheimer disease AB Science Not yet recruiting No outcome recorded
Phase 3 NCT07060391 Comparator Jul 2025 → Jan 2027 expected Alzheimer disease Shanghai Jiao Tong University School of Medicine Not yet recruiting No outcome recorded
Phase 3 NCT03283059 Comparator Aug 2017 → Sep 2020 Alzheimer disease Shanghai Mental Health Center Unknown No outcome recorded
Phase 3 NCT02822573 Comparator May 2017 → Jul 2022 amnestic disorder Wake Forest University Health Sciences Completed No outcome recorded
Phase 3 NCT02453932 Comparator Oct 2013 → May 2017 vascular dementia Dongzhimen Hospital, Beijing Completed No outcome recorded
Phase 418 trials
Phase 4 NCT07604896 Comparator Jan 2026 → Dec 2027 expected Alzheimer disease First Affiliated Hospital of Wenzhou Medical University Recruiting No outcome recorded
Phase 4 NCT03954613 Background Oct 2020 → Mar 2023 Alzheimer disease Neutec Ar-Ge San ve Tic A.Ş Unknown No outcome recorded
Phase 4 NCT03299257 Comparator Jul → Nov 2018 hypersomnia, obstructive sleep apnea syndrome Associação Fundo de Incentivo à Pesquisa Unknown No outcome recorded
Phase 4 NCT03441516 Comparator Apr 2018 → Jul 2019 Alzheimer disease Yuhan Corporation Unknown No outcome recorded
Phase 4 NCT03151382 Background May → Dec 2017 Alzheimer disease Zhejiang Provincial People's Hospital Unknown No outcome recorded
Phase not applicable12 trials
NCT07351773 Background Jan → Jun 2025 Alzheimer disease Taizhou Second People's Hospital Completed No outcome recorded
NCT06417086 Background Jun 2024 → Nov 2026 expected Alzheimer disease ZhanYJ Recruiting No outcome recorded
NCT05078944 Background Jun 2022 → Sep 2025 Alzheimer disease type 1 Shanghai Institute of Acupuncture, Moxibustion and Meridian Completed No outcome recorded
NCT05518409 Background Apr 2022 → Dec 2023 Alzheimer disease, Lewy body dementia First Affiliated Hospital of Zhejiang University Unknown No outcome recorded
NCT04732182 Background Feb → Dec 2022 Alzheimer disease Bright Cloud International Corp Unknown No outcome recorded

Press releases naming this drug 2 releases

DateIssuerRelease
2008-03-28 Teva Branded Pharmaceutical Products R&D, Inc. Teva Provides Update On Generic Aricept® Litigation tevapharm.com
2008-01-14 Teva Branded Pharmaceutical Products R&D, Inc. Teva Announces Tentative Approval Of Generic Aricept® Tablets tevapharm.com

Evidence & citations 42 cited values

Every value below carries the sentence it was read from. 292 sources stand behind the page.

FieldValueCited text
Known as donepezil “Battery of medications provided through a 12-week schedule including: Minocycline, Lamotrigine, Flumazenil, Modafinil, Bromocriptine, Donepezil, Methylphenidate, Methyl B12,...” NCT02696512
256

“This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of donepezil...” PMID 40444644 May 2025

Donepezil will be used at initial dose of 2.5 mg/day (during the first two weeks), and an increased dose of 5 mg/day (from the 3rd week and on), according to the treatment...” NCT01098383

“Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe...” NCT01539031

“A Phase 1, Randomized, Open-Label, Exploratory, Sequential, Pharmacokinetic Single Ascending Dose Study of IVL3003 Versus Multiple Doses of Aricept (Donepezil) Tablets in...” NCT05345509

“In titration period, donepezil 5-mg tablet will be taken orally once daily for 6 weeks, following donepezil 10 mg tablets taken orally once daily for 18 weeks in the maintenance period.” NCT01404169

“A 12-Week, Multicenter, Open-Label Study to Evaluate the Effectiveness and Safety of Donepezil Hydrochloride (Aricept) in Hispanic Patients With Mild to Moderate Alzheimer's Disease” NCT00230568

Donepezil will then be added to duloxetine 120mg qam (or the highest dose the patient can tolerate if it is lower than 120mg) by 5mg qd for 1 week, followed by 10mg qd for 1 week.” NCT02857244

“Conventional anti-dementia treatment: Early-stage Alzheimer's disease (AD) patients routinely take cholinesterase inhibitors such as donepezil for treatment.” NCT07604896

“Patients in the medication group received only the currently recognized pharmacological treatments for AD, including Memantine Hydrochloride and Donepezil.” NCT07094438

“23 mg donepezil sustained release (SR) concurrently with placebo identical in appearance to the 10 mg donepezil immediate release (IR) formulation” NCT01276353

“The investigators will identify Veterans who have been taking a cholinesterase inhibitor (CI) (donepezil or galantamine) for at least one year.” NCT02248636

Donepezil: Subjects will take 5 mg/day of donepezil in the evening for first 4 weeks, then 10 mg/day of donepezil in the evening until week 13.” NCT04318639

“Drug intervention group AD patients with drug regimen (donepezil 5mg / d) and primary care guidance, once every three months follow-up.” NCT04754152

“Levels of acetylcholine in the cerebral cortex will be enhanced by administration of donepezil, an inhibitor of acetylcholinesterase.” NCT05003063

“This study is to evaluate the safety and tolerability of single dose of GB-5001 (donepezil) IM and SC depot in healthy male Adults.” NCT06127368

“stable dose of cholinesterase inhibitor (donepezil, rivastigmine or galantamine) and/or memantine, as per standard practice.” NCT01872598

“GB-5001 is an intramuscular (IM) formulation of donepezil under development for the treatment of Alzheimer's disease.” PMID 39126603 Aug 2024

“with either galantamine hydrobromide (AChEI + nicotinic receptor modulation) or donepezil hydrochloride (AChEI only)” NCT00369603

“The Efficacy, Tolerability and Safety of Donepezil (Aricept) in Parkinson's Disease Patients With Dementia” NCT00165815

“Open-label donepezil tablets (dose strength: 10 mg) administered orally, QD on Days 1-14.” NCT03740178

Donepezil, Rivastigmine, Galantamine were given in combination for Alzheimer's disease.” NCT05102045

“Cholinesterase inhibitors (donepezil, rivastigmine or galantamine) and/or memantine” NCT05564169

“mild cognitive impairment (donepezil, rivastigmine, memantine)” NCT02670161

“Drug: Donepezil Hydrochloride 10 mg orally for 12 months” NCT00403520

“7 days of 5 mg donepezil QD; 14 days 10 mg QD (Period 2)” NCT01097876

Donepezil: 10 mg total daily dose, administered orally” NCT01852110

Donepezil 10 mg Oral Tablet qd for 24 weeks” NCT03441516

“Oral Donepezil (5 mg QD for 6 Weeks)” NCT00483028

Donepezil/Memantin Combination” NCT03954613

Donepezil - 5 mg or 10 mg” NCT02035982

“solifenacin and donepezilNCT02860065

NCT01023425

NCT02822573

NCT01024660

NCT00165763

NCT05811000

NCT00866060

NCT06518941

NCT03569579

NCT00062972

NCT02415062

NCT00196690

NCT01082965

NCT01297036

NCT00571064

NCT00177671

NCT01014858

NCT00004807

NCT06774261

NCT00887601

NCT03030105

NCT00533065

NCT00006349

NCT04117178

NCT02918266

NCT02255799

NCT01250977

NCT00505167

NCT03316898

NCT07680660

NCT00182884

NCT00206947

NCT05641480

NCT03454646

NCT01845636

NCT00030979

NCT00768261

NCT00293176

NCT05078944

NCT01146509

NCT00708552

NCT00501111

NCT00754052

NCT03907371

NCT00530478

NCT01466088

NCT00352664

NCT04308304

NCT01677754

NCT00142324

NCT00912808

NCT02787746

NCT06687993

NCT05042102

NCT02206620

NCT02064920

NCT03090516

NCT00408525

NCT00182845

NCT03905096

NCT02264353

NCT04617782

NCT00959881

NCT02331771

NCT00630851

NCT00967707

NCT01278407

NCT01461174

NCT00457769

NCT00693004

NCT01044342

NCT03599726

NCT00096473

NCT00911807

NCT00777608

NCT03397862

NCT02055703

NCT03109314

NCT01379001

NCT00695136

NCT01738295

NCT04505670

NCT01940952

NCT01439243

NCT06041789

NCT00465283

NCT01018875

NCT05538507

NCT00174382

NCT02635750

NCT00948909

NCT00452868

NCT01860625

NCT00754013

NCT01951118

NCT01658228

NCT00713765

NCT02549196

NCT01633593

NCT00688376

NCT01451749

NCT00543855

NCT00519298

NCT01527916

NCT00467766

NCT01439230

NCT00006399

NCT03151382

NCT02988908

NCT02453932

NCT02406261

NCT02769065

NCT05438264

NCT01023867

NCT03011476

NCT00482001

NCT01063556

NCT05518409

NCT05254639

NCT01191918

NCT02968719

NCT00868010

NCT00070161

NCT00602680

NCT00165724

NCT01181310

NCT01521117

NCT05709301

NCT00711204

NCT00477659

NCT03055741

NCT00766363

NCT04134416

NCT06417086

NCT00916383

NCT03438604

NCT00381381

NCT02450786

NCT00165659

NCT01485185

NCT00267163

NCT01887132

NCT01849042

NCT06393413

NCT04423276

NCT00480870

NCT01490567

NCT00619983

NCT03432195

NCT01584076

NCT01487395

NCT01345864

NCT02550665

NCT00369785

NCT01822951

NCT02178124

NCT01743976

NCT00220896

NCT01125683

NCT02927522

NCT00675025

NCT00151398

NCT01327859

NCT00776347

NCT00047697

NCT01213355

NCT02374567

NCT00934531

NCT03810794

NCT03197740

NCT02097056

NCT00315367

NCT01120626

NCT00566501

NCT01362686

NCT00570128

NCT02087865

NCT00423228

NCT00750529

NCT02305836

NCT03698695

NCT04661280

NCT01137526

NCT01266525

NCT00805792

NCT00478205

NCT00710684

NCT00069550

NCT00188812

NCT00874939

NCT00586196

NCT01923259

NCT07153991

NCT04730635

NCT00190021

NCT00348192

NCT00139373

NCT00227994

NCT00220584

NCT07208344

NCT06903910

NCT03299257

NCT02094053

NCT00000173

NCT02051335

NCT00895895

NCT02580305

NCT00800553

NCT01255046

NCT04507438

NCT00043589

NCT02337907

NCT01923558

NCT00912457

NCT02487082

NCT06373094

NCT00467389

NCT01442766

NCT01495195

NCT01042314

NCT05540977

NCT07060391

NCT00042172

NCT06285240

NCT02222727

NCT07066826

Known as [14C]DONEPEZIL HYDROCHLORIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as Adlarity ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as Aricept “And, it is to predict the multiple-dose pharmacokinetics based on the single-dose pharmacokinetics of GB-5001 IM depot and the oral Aricept® (donepezil hydrochloride) tablet by...” NCT05525780
40

“A Phase 1, Randomized, Open-Label, Exploratory, Sequential, Pharmacokinetic Single Ascending Dose Study of IVL3003 Versus Multiple Doses of Aricept (Donepezil) Tablets in...” NCT05345509

“A 12-Week, Multicenter, Open-Label Study to Evaluate the Effectiveness and Safety of Donepezil Hydrochloride (Aricept) in Hispanic Patients With Mild to Moderate Alzheimer's Disease” NCT00230568

“Randomized, Open-Label, 2-Way Crossover, Bioequivalence Study of Donepezil 10 mg Tablet and Aricept® (Reference) Following a 10 mg Dose in Healthy Subjects Under Fasting Conditions” NCT01439230

“Participant takes 10 mg of Aricept daily or wears an Exelon 9.5 mg patch and is stable on one of these medications that were prescribed for diagnostic of early Alzheimer's Disease” NCT04732182

“The purpose of this study is to examine the efficacy and safety of cholinesterase inhibitor (donepezil hydrochloride) Aricept in patients with vascular dementia (VaD).” NCT00165763

“This is a 12-week, randomized, placebo controlled study to determine if donepezil (Aricept) treatment during rehabilitation after stroke improves functional recovery.” NCT00868010

“The purpose of this study is to evaluate the effectiveness of donepezil (Aricept) for the treatment of mild cognitive impairment (MCI) in elderly adults.” NCT00042172

“Participants are instructed to take one 5mg pill (donepezil HCL \[Aricept®\]) every night before going to bed with a glass of water for 28 days.” NCT01250977

“This study will evaluate the safety and effectiveness of donepezil (Aricept) for treating mild dementia in patients with Parkinson's disease.” NCT00030979

“This study will evaluate the effectiveness of donepezil (Aricept®) and cognitive training in improving memory performance in elderly adults.” NCT00043589

“Donepezil (Aricept) 5 mg tablet orally once daily for 30 days, followed by 10 mg tablet orally once daily to complete 6 months of treatment” NCT00630851

“Donepezil (also known as Aricept) has been FDA approved for improving memory and learning in individuals with Alzheimer's disease.” NCT00062972

“Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer's disease (AD).” NCT00096473

“Donepezil (Aricept), a cholinesterase inhibitor, is used clinically to ameliorate memory-related cognitive deficits.” PMID 29336496 Feb 2018

“Donepezil HCI (Aricept®) is an FDA-approved drug now used to enhance memory in patients with Alzheimer's disease.” NCT00315367

“Patients were randomized to receive placebo thrice daily, or octohydroaminoacridine 4 mg/TID or ARICEPT 5mg/QD.” NCT03283059

“Safety, Tolerability, and Efficacy of Donepezil (Aricept) in Parkinson' s Disease (PD) Patients With Dementia” NCT01327859

“The Efficacy, Tolerability and Safety of Donepezil (Aricept) in Parkinson's Disease Patients With Dementia” NCT00165815

Aricept® Orally Disintegrating Tablets, Manufactured and Marketed by Eisai Inc.” NCT01260922

Aricept® Orally Disintegrating Tablets, Manufactured and Marketed by Eisai Inc.” NCT01260948

“The substance donepezil (under the brand name Aricept®) is a resale product.” NCT06774261

“Drug-Drug Interaction Study With Aricept® (Donepezil)” NCT01042314

Aricept (5 mg and 10 mg) Donepezil Hydrochloride” NCT02968719

Aricept 5 mg (donepezil hydrochloride) drug” NCT05811000

Aricept (donepezil hydrochloride)” NCT00754052

Aricept (donepezil hydrochloride)” NCT01146509

Aricept (Donepezil hydrochloride)” NCT00754013

“Donepezil Oral Tablet (Aricept®)” NCT06127368

Aricept (donepezil SR 23 mg)” NCT00478205

“Donepezil (Aricept®)” NCT00768261

“Donepezil (Aricept)” NCT00467766

“Donepezil (Aricept)” NCT06903910

NCT04479865

NCT01245530

NCT03283059

NCT05127746

NCT00031018

NCT00018278

NCT00934375

NCT00103948

Known as ARICEPT Donépezil “ARICEPT ® Donépezil” NCT01487395
2

“Aricept (donepezil)” NCT01181310

“Aricept (Donepezil)” NCT00505167

Known as Aricept evess ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as Aricept odt ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as Aricept Tablet Aricept TabletNCT02968719
Known as Aricept(Registered Trademark) “This study will test whether donepezil (Aricept(Registered Trademark)), a drug that is approved by the Food and Drug Administration to treat Alzheimer's disease” NCT00695136
Known as BNAG ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as Brand name for donepezil: Aricept Brand name for donepezil: AriceptNCT00911807
Known as Corplex Donepezil TDS Corplex Donepezil TDSNCT02968719
Known as D797 ClinicalTrials.gov intervention name — accepted as the source's own label NCT03802162
Known as DKF-310 ClinicalTrials.gov intervention name — accepted as the source's own label NCT02695004
Known as Donaz ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as donepezil (Aricept) donepezil (Aricept)NCT00934531
Known as Donepezil (generic name) Donepezil (generic name)NCT01439243
1

Donepezil (generic name)NCT01439230

Known as Donepezil Dihydroxynaphthalate “A Single-center, Open-label, Single-dose Ascending Phase I Clinical Study Evaluating the Safety, Tolerability, and Pharmacokinetic Profile of HHT201 (Donepezil...” NCT06373094
Known as Donepezil HCI Donepezil HCI (Aricept®) is an FDA-approved drug now used to enhance memory in patients with Alzheimer's disease.” NCT00315367
Known as Donepezil HCl “5 mg donepezil HCl given once a day and increased to 10 mg per day if side effects, when present, are tolerated.” NCT00165763
4

donepezil HCL (a cholinesterase inhibitor)” NCT02087865

“Drug: Donepezil HClNCT00571064

“Drug: Donepezil HClNCT00570128

“Drug: Donepezil HClNCT00047697

Known as Donepezil Hydrochloride “A 3-year, double-blind, placebo-controlled Alzheimer's Disease Cooperative Study initially designed to evaluate the efficacy of donepezil hydrochloride or vitamin E vs placebo...” PMID 17210817 Jan 2007
34

“A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe...” NCT01404169

“And, it is to predict the multiple-dose pharmacokinetics based on the single-dose pharmacokinetics of GB-5001 IM depot and the oral Aricept® (donepezil hydrochloride) tablet by...” NCT05525780

“A 12-Week, Multicenter, Open-Label Study to Evaluate the Effectiveness and Safety of Donepezil Hydrochloride (Aricept) in Hispanic Patients With Mild to Moderate Alzheimer's Disease” NCT00230568

“This proposal is for a 6 to 20 week, single arm, open-label study to evaluate the ability of donepezil hydrochloride to enhance REM sleep in children with autism spectrum disorder” NCT00695136

“The purpose of this study is to examine the efficacy and safety of cholinesterase inhibitor (donepezil hydrochloride) Aricept in patients with vascular dementia (VaD).” NCT00165763

Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer's disease (AD).” NCT00096473

Donepezil Hydrochloride (E2020) In Subjects With Mild To Severe Alzheimer's Disease Residing In An Assisted Living Facility” NCT00571064

“The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)” NCT00293176

“with either galantamine hydrobromide (AChEI + nicotinic receptor modulation) or donepezil hydrochloride (AChEI only)” NCT00369603

Donepezil hydrochloride tablets 5 mg, once a day, one tablet each time, before going to bed.” NCT05641480

“Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture.” PMID 22091574 Nov 2011

Donepezil Hydrochloride Transdermal Delivery System (5mg and 10 mg Version B)” NCT02968719

“Drug: Donepezil Hydrochloride 10 mg orally for 12 months” NCT00403520

“Test- Donepezil Hydrochloride 10 mg Tablet single dose” NCT01297036

“Aricept 5 mg (donepezil hydrochloride) drug” NCT05811000

Donepezil Hydrochloride (Aricept®)” NCT00570128

Donepezil hydrochloride (Aricept)” NCT00675025

Donepezil Hydrochloride (Aricept)” NCT00711204

“Drug: donepezil hydrochlorideNCT00006349

“E2020-Donepezil hydrochlorideNCT02094053

“Drug: Donepezil HydrochlorideNCT03151382

“Drug: Donepezil hydrochlorideNCT00688376

“Drug: Donepezil HydrochlorideNCT03907371

NCT03932916

NCT01260948

NCT01466270

NCT00165750

NCT00165737

NCT03073876

NCT04013477

NCT07351773

NCT01260922

NCT01903824

NCT02660983

Known as Donepezil Hydrochloride (generic name) Donepezil Hydrochloride (generic name)NCT01260922
Known as Donepezil hydrochloride component of namzaric ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as DONEPEZIL HYDROCHLORIDE MONOHYDRATE ChEMBL registry synonym — accepted as the source's own label CHEMBL502
Known as Donepezil TDS “Drug: Donepezil TDSNCT03397862