Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil

Summary

This study is to compare the safety and effects of donepezil (Aricept) for patients reporting cognitive or memory issues after receiving chemotherapy for breast cancer. Patients will receive either donepezil or placebo for 24 weeks. The primary objective is to see if memory improves with the use of donepezil during the study.

Timeline

Start

2017-05-30

Primary completion

2022-07-29

Completion

2022-07-29

Publications

• Rapp SR, Dressler EV, Brown WM, Wade JL 3rd, Le-Lindqwister N, King D, Rowland KM, Weaver KE, Klepin HD, Shaw EG, Lesser GJ. Phase III Randomized, Placebo-Controlled Clinical Trial of Donepezil for Treatment of Cognitive Impairment in Breast Cancer Survivors After Adjuvant Chemotherapy (WF-97116). J Clin Oncol. 2024 Jul 20;42(21):2546-2557. doi: 10.1200/JCO.23.01100. Epub 2024 May 6.

Drugs

Indications