The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease
Summary
Objectives: The purpose of this study was to investigate the effects of high-frequency repetitive Transcranial Magnetic Stimulation (rTMS) in Alzheimer's Disease (AD). Methods: Twenty-seven AD patients aged ≥60 years were included in the study and divided into 3 groups (rTMS, Aerobic Exercise (AE) and control). All groups received pharmacological treatment. rTMS group (n=10) received 20 Hz rTMS treatment on bilateral dorsolateral prefrontal cortex, 5 days a week over 2 weeks, and AE group (n=10) received the moderate-intensity aerobic exercise for 50 min sessions, 5 days a week over 2 weeks. Control group (n=10) was only treated pharmacologically. Neuropsychiatric and behavioral status, cognition, balance, functional mobility, and quality of life, and functional brain changes were evaluated before and after the treatment.
Timeline
- Start
- 2016-09-01
- Primary completion
- 2017-05-01
- Completion
- 2017-06-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Donepezil | Small molecule | — | — |
| Background | Galantamine | Small molecule | — | — |
| Background | Memantine | Unknown | — | — |
| Background | Rivastigmine | Small molecule | — | — |