Drugs / Galantamine
Galantamine
also known as
Reminyl · galantamine hydrobromide · Galantamine ER · galantamine HBr · R113675 · Razadyne · (-)-galanthamine · Acumor xl · +26 more
Small molecule targets ACHE via inhibition
Regulatory milestones approvals, filings & regulatory actions · 1 recorded
| Milestone | Jurisdiction | Brand | Indication | Date | Sentence it was read from |
|---|---|---|---|---|---|
| Approved | US (FDA) | RAZADYNE | — | 2001-02-28 | fda.gov ↗ |
Trials 71 · started per year
today
US approved 2001
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Also used as a comparator or background therapy in 23 trials
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 02 trials | ||||||
| Phase 0 | NCT07208344 Background | Jul → Dec 2025 overdue | Alzheimer disease | Anhui Provincial Hospital | Recruiting | No outcome recorded |
| Phase 0 | NCT03547622 Comparator | May 2018 → Feb 2019 | — | Yale University | Completed | No outcome recorded |
| Phase 13 trials | ||||||
| Phase 1 | NCT01417429 Comparator | Mar 2010 → Mar 2011 | substance withdrawal syndrome | Yale University | Completed | No outcome recorded |
| Phase 1 | NCT01039194 Comparator | Jan → Apr 2010 | Alzheimer disease | Bristol-Myers Squibb | Completed | No outcome recorded |
| Phase 1 | NCT00969696 Comparator | Aug 2009 → Jun 2011 | — | Yale University | Completed | No outcome recorded |
| Phase 25 trials | ||||||
| Phase 2 | NCT01852110 Background | Oct 2013 → Apr 2016 | Alzheimer disease | Merck Sharp & Dohme LLC | Terminated | No outcome recorded |
| Phase 2 | NCT01677754 Background | Oct 2012 → Jun 2015 | Alzheimer disease | Hoffmann-La Roche | Completed | No outcome recorded |
| Phase 2 | NCT01416948 Comparator | Aug 2011 → Mar 2013 | post-traumatic stress disorder, traumatic brain injury | INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium | Terminated | No outcome recorded |
| Phase 2 | NCT01508494 Comparator | Jun 2011 → Jun 2016 | cognitive disorder, stroke disorder | French National Institute of Health and Medical Research | Completed | No outcome recorded |
| Phase 2 | NCT01012167 Comparator | Feb 2010 → Jul 2014 | schizophrenia | University of Maryland, Baltimore | Completed | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT02098824 Comparator | Feb 2014 → Dec 2016 | vascular dementia | Amsterdam UMC, location VUmc | Unknown | No outcome recorded |
| Phase 34 trials | ||||||
| Phase 3 | NCT05564169 Background | Jun 2026 → Dec 2028 expected | Alzheimer disease | AB Science | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT01872598 Background | Jan 2012 → Dec 2020 | Alzheimer disease | AB Science | Completed | No outcome recorded |
| Phase 3 | NCT02035982 Comparator | Jul 2010 → May 2014 | Alzheimer disease | Sunnybrook Health Sciences Centre | Completed | No outcome recorded |
| Phase 3 | NCT00566735 Comparator | Jul 2004 → Jan 2008 | bipolar depression, major depressive disorder, schizoaffective disorder | Massachusetts General Hospital | Completed | No outcome recorded |
| Phase 43 trials | ||||||
| Phase 4 | NCT07284290 Comparator | Dec 2025 → Nov 2029 expected | Lewy body dementia, Parkinson disease | Virginia Commonwealth University | Recruiting | No outcome recorded |
| Phase 4 | NCT00523666 Comparator | Sep 2006 → Sep 2008 | Alzheimer disease | Ludwig-Maximilians - University of Munich | Unknown | No outcome recorded |
| Phase 4 | NCT00626613 Background | — | Alzheimer disease | Jinan Mental Hospital | Unknown | No outcome recorded |
| Phase not applicable5 trials | ||||||
| — | NCT05102045 Background | Sep 2016 → May 2017 | Alzheimer disease | Istanbul Medipol University Hospital | Completed | No outcome recorded |
| — | NCT01880099 Comparator | Dec 2013 → Dec 2015 | nicotine dependence | Yale University | Completed | No outcome recorded |
| — | NCT01531153 Comparator | Sep 2011 → Jun 2016 | substance dependence | Yale University | Completed | No outcome recorded |
| — | NCT00606801 Comparator | Jun 2007 → Feb 2009 | cocaine abuse | Yale University | Completed | No outcome recorded |
| — | NCT01129479 Comparator | Oct 2004 → Dec 2007 | aphasia, stroke disorder | University of North Carolina, Chapel Hill | Completed | No outcome recorded |
Evidence & citations 39 cited values
Every value below carries the sentence it was read from. 97 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | galantamine | “The investigators will identify Veterans who have been taking a cholinesterase inhibitor (CI) (donepezil or galantamine) for at least one year.” NCT02248636 ↗90“stable dose of cholinesterase inhibitor (donepezil, rivastigmine or galantamine) and/or memantine, as per standard practice.” NCT01872598 ↗ “with either galantamine hydrobromide (AChEI + nicotinic receptor modulation) or donepezil hydrochloride (AChEI only)” NCT00369603 ↗ “Donepezil, Rivastigmine, Galantamine were given in combination for Alzheimer's disease.” NCT05102045 ↗ “Cholinesterase inhibitors (donepezil, rivastigmine or galantamine) and/or memantine” NCT05564169 ↗ “Galantamine: 16-24 mg total daily dose, administered orally” NCT01852110 ↗ “Galantamine - 8 mg and 16 mg and 24 mg” NCT02035982 ↗ |
| Known as | (-)-galanthamine | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Acumor xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Consion xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Elmino xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | GAL | “The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life” NCT00814658 ↗ |
| Known as | Galantamina | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Galantamine ER | “Galantamine-ER for cognitive dysfunction in bipolar disorder and correlation with hippocampal neuronal viability: a proof-of-concept study.” PMID 19889129 ↗ 20091“Drug: Galantamine ER” NCT01548638 ↗ |
| Known as | galantamine HBr | “Galantamine HBr, a tertiary alkaloid, is a competitive and reversible inhibitor of acetylcholinesterase” NCT00181675 ↗1“Galantamine HBr extended-release 8mg capsules (8mg ER).” NCT07284290 ↗ |
| Known as | galantamine hydrobromide | “Study medications will be given as a single dose before the Day 2 session which will produce ascending plasma drug levels (t= ½ 5/7 h) during the two hour testing session, in a...” NCT00463879 ↗2“The purpose of this study is to assess the effectiveness and safety of galantamine hydrobromide treatment in patients with severe Alzheimer's disease.” NCT00216593 ↗ “with either galantamine hydrobromide (AChEI + nicotinic receptor modulation) or donepezil hydrochloride (AChEI only)” NCT00369603 ↗ |
| Known as | galantamine hydrobromide-ER | “The study will be performed using the 8mg and 16mg doses of galantamine hydrobromide-ER, which is currently marketed for the treatment of Alzheimer's disease.” NCT01548638 ↗ |
| Known as | galantamine hydrochloride | “The proposed study will entail a comprehensive evaluation of the effects of acute doses of the nAChR allosteric modulator galantamine hydrochloride (0, 4 and 8 mg) on...” NCT00463879 ↗ |
| Known as | Galantamine-CR | “The purpose of the study is to determine whether the investigational drug galantamine-CR (Reminyl- Controlled Release capsule) is useful in improving problems with memory in...” NCT00181636 ↗ |
| Known as | Galanthamine hydrobromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Galsya xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Galzemic xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Gatalin xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Gazylan xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Jilkon hydrobromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Lotprosin xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Luventa xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Lycoremine hydrobromide | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Nivalin | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Nivaline | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | NSC-100058 | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | R113675 | “Placebo-Controlled, Double-Blind Study of Galantamine (R113675) in the Treatment of Alzheimer's Disease.” NCT00301574 ↗1“Placebo-controlled Confirmatory Study of Galantamine (R113675) for Alzheimer's Type Dementia” NCT00814801 ↗ |
| Known as | Razadyne | “This is a preliminary open-label study to determine whether a medication called galantamine (Brand Name: Razadyne) will help smokers quit and whether it reduces cognitive...” NCT01548638 ↗ |
| Known as | Razadyne er | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Reminyl | “Galantamine (Trade name: Reminyl) is a new FDA-approved selective acetylcholinesterase inhibitor (AChEI), which may also allosterically modulate nicotinic receptors, enhance...” NCT00176423 ↗4“Safety and efficacy of galantamine (Reminyl) in severe Alzheimer's disease (the SERAD study): a randomised, placebo-controlled, double-blind trial.” PMID 19042161 ↗ Nov 2008 “Galantamine (Reminyl®)” NCT00523666 ↗ |
| Known as | Reminyl ER | “The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life” NCT00814658 ↗ |
| Known as | Reminyl PRC | “The primary objective is the assessment of the modulating effect of galantamine (Reminyl PRC) on circadian rhythm (wake/sleep) in patients with moderate Alzheimer's disease.” NCT01181921 ↗ |
| Known as | Reminyl xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Reminyl- Controlled Release capsule | “The purpose of the study is to determine whether the investigational drug galantamine-CR (Reminyl- Controlled Release capsule) is useful in improving problems with memory in...” NCT00181636 ↗ |
| Known as | Tamilin | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Known as | Zeebral xl | ChEMBL registry synonym — accepted as the source's own label CHEMBL659 ↗ |
| Action | Inhibit | “It inhibits an enzyme that breaks down acetylcholine” NCT00000172 ↗1“Acetylcholinesterase inhibitor” CHEMBL659 ↗ |
| Modality | Small molecule | “Galantamine HBr, a tertiary alkaloid” NCT00181675 ↗ |
| Route | Oral | “Galantamine will be given by mouth 4mg twice daily for Weeks 1-4 and then 8mg twice daily for Weeks 5-8 and beyond” NCT00035204 ↗ |
| Target | ACHE | “Acetylcholinesterase inhibitor” CHEMBL659 ↗ |