Racial Differences in Vagal Control of Glucose Homeostasis

Phase 1/2 Completed 23 enrolled Vanderbilt University Medical Center Doris Duke Charitable Foundation · collab

RandomizedCrossoverDouble-blindTreatment

Summary

The investigators will test the hypothesis that acute central acetylcholinesterase inhibition will restore PNS activity and reduce oxidation in AAW compared to whites.

Timeline

Start: 2015-03
Primary completion: 2017-10-05
Completion: 2017-10-05

Outcome

Met primary endpoint

paper Compared to placebo, 16 mg of galantamine significantly inhibited the increase in F2-IsoPs in PBMC (0.007 ± 0.008 vs. - 0.002 ± 0.006 ng/sample, P = 0.016) PMID 35659521 ↗

paper Compared to placebo, 16 mg of galantamine significantly inhibited the increase in F2-IsoPs in PBMC PMID 35659521 ↗

Publications

Parsa D, Aden LA, Pitzer A, Ding T, Yu C, Diedrich A, Milne GL, Kirabo A, Shibao CA. Enhanced parasympathetic cholinergic activity with galantamine inhibited lipid-induced oxidative stress in obese African Americans. Mol Med. 2022 Jun 3;28(1):60. doi: 10.1186/s10020-022-00486-5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Galantamine	Small molecule	16 mg	Oral
Background	Heparin	Other / unclassified	200 iu	Intravenous
Background	Intralipid	Other / unclassified	0.8 ml	Intravenous
Background	Intralipid	Other / unclassified	20 %	Intravenous