drugset
drugset / Trial / NCT05003063

Effects of Acetylcholine and Attention on Visual Spatial Representations in the Brain

NCT05003063 ↗

Phase 0 Completed 12 enrolled University of California, Berkeley
RandomizedCrossoverTriple-blindBasic science

Summary

This study in, healthy human subjects using fMRI and MRS (magnetic resonance spectroscopy) characterizes, how attention and acetylcholine affect visual perception and the brain's representation of the visual environment. Levels of acetylcholine in the cerebral cortex will be enhanced by administration of donepezil, an inhibitor of acetylcholinesterase. Half the subjects will receive donepezil and other half will receive placebo.

Timeline

Start
2021-02-04
Primary completion
2021-08-02
Completion
2021-08-02

Drugs

EvaluationDrugModalityDoseRoute
Comparator Donepezil Small molecule 2.5 mg Oral
Comparator Donepezil Small molecule 5 mg Oral
Comparator Donepezil Small molecule 10 mg Oral

Indications

No indication recorded.