drugset / Trial / NCT07094438

Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease

NCT07094438

Phase 1 Recruiting 98 enrolled Chinese PLA General Hospital
RandomizedCrossoverSingle-blindTreatment

Summary

To investigate the safety of deep brain stimulation (DBS) and cervical deep lymphoid-venous anastomosis (LVA) in the treatment of severe Alzheimer's disease (AD); to investigate the effectiveness of DBS and LVA in the treatment of severe AD, i.e., effects of deep brain stimulation on cognitive function, emotion and life quality in patients with severe AD.

Timeline

Start
2025-01-01
Primary completion
2026-06
Completion
2027-07

Drugs

EvaluationDrugModalityDoseRoute
Comparator Donepezil Small molecule
Comparator Memantine Unknown

Indications