drugset / Trial / NCT03030105
Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers
RandomizedCrossoverDouble-blindTreatment
Summary
This is a Phase 1, randomized, double-blind, placebo-controlled, 6-period crossover study to evaluate the effects of BPN14770 10 mg and 50 mg in reversing scopolamine-induced cognitive impairment in healthy volunteers. A positive control, donepezil 10 mg, will be included, and additivity of BPN14770 50 mg to donepezil 10 mg in reversing scopolamine effects will also be evaluated.
Timeline
- Start
- 2017-01
- Primary completion
- 2017-05
- Completion
- 2017-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Donepezil | Small molecule | 10 mg | Oral |
| Subject | Scopolamine | Unknown | 0.5 mg | Subcutaneous |
| Subject | zatolmilast | Small molecule | 10 mg | Oral |
| Subject | zatolmilast | Small molecule | 50 mg | Oral |