drugset / Trial / NCT03030105

Study to Evaluate the Effects of BPN14770 on Scopolamine-induced Cognitive Impairment in Healthy Volunteers

NCT03030105

Phase 1 Completed 38 enrolled Tetra Discovery Partners
RandomizedCrossoverDouble-blindTreatment

Summary

This is a Phase 1, randomized, double-blind, placebo-controlled, 6-period crossover study to evaluate the effects of BPN14770 10 mg and 50 mg in reversing scopolamine-induced cognitive impairment in healthy volunteers. A positive control, donepezil 10 mg, will be included, and additivity of BPN14770 50 mg to donepezil 10 mg in reversing scopolamine effects will also be evaluated.

Timeline

Start
2017-01
Primary completion
2017-05
Completion
2017-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Donepezil Small molecule 10 mg Oral
Subject Scopolamine Unknown 0.5 mg Subcutaneous
Subject zatolmilast Small molecule 10 mg Oral
Subject zatolmilast Small molecule 50 mg Oral

Indications