drugset / Trial / NCT05540977

Donepezil Prevents Urinary Retention After Extensive Total Hysterectomy

NCT05540977

RandomizedParallel-groupOpen-labelPrevention

Summary

Patients were randomly divided into experimental group and control group. The control group received routine postoperative treatment, while the experimental group took donepezil 5mg orally before going to bed every night from the first day after surgery. The catheter was removed and residual urine was measured in both groups 14 days after surgery, the catheter was successfully removed when the residual urine was less than 100ml. After 14 days, the patient was returned to the hospital for residual urine test, and the residual urine was repeated until the residual urine volume was less than or equal to 100ml. The incidence of postoperative urinary retention and adverse drug reactions were compared between the two groups.

Timeline

Start
2022-08-01
Primary completion
2023-05-31
Completion
2023-07-15

Drugs

EvaluationDrugModalityDoseRoute
Subject Donepezil Small molecule 5 mg Oral

Indications

No indication recorded.