Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI

Summary

This research study will look at how medications affect the pattern of blood flow in the brain. This study will use a special type of MRI (magnetic resonance imaging) scan called perfusion MRI to make measurements of cerebral (brain) blood flow. The medications we will use in this study are scopolamine (commonly used to treat motion sickness), mecamylamine (used to treat high blood pressure), and donepezil (used to treat memory loss). Cognitive testing will also be obtained, and correlated with the blood flow patterns in the brain.

Timeline

Start

2008-07

Primary completion

2013-01

Completion

2013-01

Drugs

Indications

No indication recorded.