Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

Phase 2 Recruiting 160 enrolled VA Connecticut Healthcare System National Institute on Alcohol Abuse and Alcoholism (NIAAA) · collab Yale University · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The goal of the project is to evaluate whether donepezil + cognitive remediation therapy is superior to placebo in reducing heavy drinking in patients with alcohol use disorder in a double-blind, placebo-controlled trial.

Timeline

Start: 2022-08-08
Primary completion: 2026-10-31
Completion: 2026-10-31

Publications

Yoon G, Sofuoglu M, Petrakis IL, Pittman B, Bell MD. The combination of donepezil and cognitive training for improving treatment outcomes for alcohol use disorder: Design of a randomized controlled trial. Contemp Clin Trials. 2024 Oct;145:107657. doi: 10.1016/j.cct.2024.107657. Epub 2024 Aug 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Donepezil	Small molecule	10 mg	Oral

Donepezil and Cognitive Training for Alcohol Use Disorder (AUD)

Summary

Timeline

Publications

Drugs

Indications