Acute Effects Of Donepezil On Brain Perfusion And Memory In Subjects With Cognitive Impairment And Mild Alzheimer's Disease
Summary
The study hypothesizes that donepezil will have a positive impact on brain blood flow deficits in subjects with memory deficits and/or mild dementia and that improvements in brain blood flow will be accompanied by improvements in memory.
Timeline
- Start
- 2010-07
- Primary completion
- 2012-07
- Completion
- 2012-07
Outcome
Missed primary endpoint
Stopped (Enrollment): “The study was terminated because of slow enrollment. The decision to terminate the trial was not based on any safety or efficacy concerns.”
registry analysis (superiority or other test); Donepezil vs Placebo; p = 0.9742; Leasts Square (LS) Mean -0.01 (95% CI -0.60 to 0.58) NCT01082965 ↗
registry analysis (superiority or other test); Donepezil vs Placebo; p = 0.9638; LS Mean Difference -0.01 (95% CI -0.51 to 0.49) NCT01082965 ↗
registry analysis (superiority or other test); Donepezil vs Placebo; p = 0.2548; LS Mean Difference -0.19 (95% CI -0.53 to 0.16) NCT01082965 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Donepezil | Small molecule | 10 mg | — |