drugset

drugset / Trial / NCT05078944

Progress of Mild Alzheimer's Disease in Participants on Acupuncture Versus Sham Acupuncture

NCT05078944 ↗

Completed 160 enrolled Shanghai Institute of Acupuncture, Moxibustion and Meridian

RandomizedParallel-groupTriple-blindTreatment

Summary

To determine if adjunctive acupuncture acts as an AD treatment rather than a placebo.

Timeline

Start: 2022-06-30
Primary completion: 2025-09-10
Completion: 2025-09-10

Publications

Kong X, Han R, Fan X, Wei K, Ma Z, Yang G, Zhao Y, Yang Y, Yang Y, Hong J, Liu J, Zhang D, Ma X. Acupuncture as an adjunct therapy for mild Alzheimer's disease: A randomized clinical trial. J Alzheimers Dis. 2026 May;111(2):757-767. doi: 10.1177/13872877261435880. Epub 2026 Mar 30.
Kong X, Ma Z, Tang R, Wang X, Wei K, Yang G, Yang Y, Zhao Y, Zhang D, Xie C, Wang G, Ma X. Efficacy of acupuncture in patients with mild Alzheimer's disease and its impact on gut microbiota: Study protocol for a randomized sham-controlled trial. Front Med (Lausanne). 2023 Feb 23;10:1014113. doi: 10.3389/fmed.2023.1014113. eCollection 2023.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Donepezil	Small molecule	5 mg	—

Indications