drugset / Trial / NCT00006399
Effects of Estrogen on Memory in Post-Menopausal Women and Patients With Alzheimer's Disease
Phase 2
Completed
45 enrolled
National Center for Research Resources (NCRR)
Alzheimer's Association · collabEisai Inc. · collabPfizer · collab
Double-blindTreatment
Summary
The goal of this study is to examine whether the administration of estrogen to post-menopausal women and women with mild to moderate Alzheimer's disease will enhance their memory and their capacity for learning.
Timeline
- Start
- 1999-09
- Primary completion
- 2004-03
- Completion
- 2004-03
Publications
- Background Newhouse PA, Potter A, Corwin J, Lenox R. Acute nicotinic blockade produces cognitive impairment in normal humans. Psychopharmacology (Berl). 1992;108(4):480-4. doi: 10.1007/BF02247425.
- Background Newhouse PA, Potter A, Corwin J, Lenox R. Age-related effects of the nicotinic antagonist mecamylamine on cognition and behavior. Neuropsychopharmacology. 1994 Apr;10(2):93-107. doi: 10.1038/npp.1994.11.
- Background Newhouse PA, Potter A, Corwin J, Lenox, R. Effects of nicotinic cholinergic agents on cognitive functioning in Alzheimer's and Parkinson's disease. Drug Development Research 38:278-289, 1996.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | conjugated estrogens | Other / unclassified | — | — |
| Background | Donepezil | Small molecule | — | — |
| Background | Progesterone | Other / unclassified | — | — |