fMRI-behavioral Study of Cholinergic Augmentation With Donepezil in Healthy Sleep Deprived Adults

Phase 4 Completed 43 enrolled Duke-NUS Graduate Medical School GlaxoSmithKline · collab

RandomizedCrossoverDouble-blindBasic science

Summary

The purpose of this study was to characterize how the anti-cholinesterase inhibitor (AChE-I) donepezil modulates brain regions involved in visual short-term memory, episodic memory and inhibitory efficiency following 24 hours of total sleep deprivation using fMRI as an additional marker for drug effect.

Timeline

Start: 2006-11
Primary completion: 2007-05
Completion: 2007-05

Publications

Results Chuah LY, Chee MW. Cholinergic augmentation modulates visual task performance in sleep-deprived young adults. J Neurosci. 2008 Oct 29;28(44):11369-77. doi: 10.1523/JNEUROSCI.4045-08.2008.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Donepezil	Small molecule	5 mg	Oral

Indications

No indication recorded.