Study of Efficacy and Safety of Valproic Acid in Chronic Lymphocytic Leukemia (CLL)

Summary

The purpose of this study is to determine whether Valproic acid, as a single agent is effective in the treatment of Chronic Lymphocytic Leukemia which has relapsed or is refractory to therapy with standard drugs.

Timeline

Start

2008-09

Primary completion

2009-03

Completion

2009-03

Publications

• Background Bokelmann I, Mahlknecht U. Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins. Mol Med. 2008 Jan-Feb;14(1-2):20-7. doi: 10.2119/2007-00084.Bokelmann.

Drugs

Indications