drugset / Trial / NCT03048084
Seizure Treatment in Glioma
Phase 4
Recruiting
120 enrolled
Leiden University Medical Center
Amsterdam UMC, location VUmc · collabErasmus Medical Center · collabMedical Center Haaglanden · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
Currently, treatment with a specific anti-epileptic drug mainly depends on the physicians' preference, as there are no studies supporting the use of one specific anticonvulsant in glioma patients. The overall aim of this randomized controlled trial is to directly compare the effectiveness of treatment with levetiracetam or valproic acid in glioma patients with a first seizure.
Timeline
- Start
- 2018-02-01
- Primary completion
- 2026-07-01
- Completion
- 2028-07-01
Publications
- van der Meer PB, Taphoorn MJB, Koekkoek JAF. Management of epilepsy in brain tumor patients. Curr Opin Oncol. 2022 Nov 1;34(6):685-690. doi: 10.1097/CCO.0000000000000876. Epub 2022 Jul 16.
- Lang F, Liu Y, Chou FJ, Yang C. Genotoxic therapy and resistance mechanism in gliomas. Pharmacol Ther. 2021 Dec;228:107922. doi: 10.1016/j.pharmthera.2021.107922. Epub 2021 Jun 23.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Levetiracetam | Other / unclassified | 1500 mg | Oral |
| Comparator | Valproic Acid | Small molecule | 1250 mg | Oral |