Valproate Versus Topiramate in Migraine

Summary

Investigators aim to compare the effect of valproate versus topiramate in migraine by assessing the reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days frequency compared to the baseline frequency.

Timeline

Start

2022-05-01

Primary completion

2024-06-10

Completion

2024-06-30

Publications

• Results Lipton RB, Scher AI, Kolodner K, Liberman J, Steiner TJ, Stewart WF. Migraine in the United States: epidemiology and patterns of health care use. Neurology. 2002 Mar 26;58(6):885-94. doi: 10.1212/wnl.58.6.885.
• Results Lipton RB, Liberman JN, Kolodner KB, Bigal ME, Dowson A, Stewart WF. Migraine headache disability and health-related quality-of-life: a population-based case-control study from England. Cephalalgia. 2003 Jul;23(6):441-50. doi: 10.1046/j.1468-2982.2003.00546.x.
• Results Mushet GR, Miller D, Clements B, Pait G, Gutterman DL. Impact of sumatriptan on workplace productivity, nonwork activities, and health-related quality of life among hospital employees with migraine. Headache. 1996 Mar;36(3):137-43. doi: 10.1046/j.1526-4610.1996.3603137.x.
• Zeinhom MG, Elsayed Khalil MF, Omar Youssif TY, Ali Daabis AM, Almoataz M, Refat HM, Mohamed Kamal Ebied AA, Atiaa Mohamed DM, Ismaiel M, Mohamed Kamel IF, Elballat AIE, Omar Akl AZ, Ahmed SR. Efficacy and tolerability of valproate versus topiramate in migraine prevention, a randomized controlled multi-center trial. J Clin Neurosci. 2025 May;135:111156. doi: 10.1016/j.jocn.2025.111156. Epub 2025 Feb 27.

Drugs

Indications