A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands

Phase 4 Terminated 2504 enrolled Ministry of Health and Medical Services, Solomon Islands World Health Organization · collab

RandomizedParallel-groupOpen-labelPrevention

Summary

The purpose of this study is to assess the effectiveness of intermittent preventive treatment in pregnancy (IPTp) with Sulphadoxine-pyrimethamine compared to chloroquine prophylaxis in Honiara, Solomon Islands for prevention of malaria and it's adverse effects in pregnancy.

Timeline

Start: 2009-08
Primary completion: 2010-08
Completion: 2010-08

Outcome

Outcome not reported

Stopped: “Low prevalence of malaria, high prevalence of reported allergy to sulphur drugs, high proportion of women not meeting the inclusion criterea.”

Publications

Wini L, Appleyard B, Bobogare A, Pikacha J, Seke J, Tuni M, Hou L, Hii J, McCarthy J, van Eijk AM. Intermittent preventive treatment with sulfadoxine-pyrimethamine versus weekly chloroquine prophylaxis for malaria in pregnancy in Honiara, Solomon Islands: a randomised trial. Malariaworld J. 2013 Jun 29;4:12. doi: 10.5281/zenodo.10894954. eCollection 2013.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Chloroquine	Small molecule	300 mg	Oral
Comparator	pyrimethamine	Small molecule	75 mg	Oral
Comparator	sulfadoxine	Small molecule	1500 mg	Oral