drugset / Trial / NCT01636895
Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria
Phase 4
Unknown
600 enrolled
Malaria Consortium, UK
Department for International Development, United Kingdom · collabLondon School of Hygiene and Tropical Medicine · collabUniversity of Nigeria, Enugu Campus · collab
NaSingle-groupOpen-labelPrevention
Summary
The study has two components: component A is a cohort study to determine the in vivo efficacy of SP to clear and prevent malaria parasitaemia in asymptomatic pregnant women and component B is a cross sectional study of women delivering at the study hospitals to assess the effectiveness of SP-IPTp to reduce adverse maternal and birth outcomes in the current context of increasing SP resistance. Results of component A and B studies will be used to model the relationship between the prevalence of molecular markers of SP resistance, in vivo efficacy to clear parasite and the effectiveness of SP-IPTp and to develop guidelines for routine monitoring effectiveness of SP-IPTp as part of ANC surveillance.
Timeline
- Start
- 2011-01
- Primary completion
- 2012-11
- Completion
- 2013-02
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | pyrimethamine | Small molecule | 25 mg | — |
| Subject | sulfadoxine | Small molecule | 500 mg | — |