Drugs / aleglitazar
last change Jan 2019 re-read 2 minutes ago

aleglitazar

also known as R-1439 · RO0728804

Small molecule targets PPARA, PPARG via activation

Developed for
type 2 diabetes mellitus · diabetes mellitus, noninsulin-dependent, 2 · diabetic kidney disease
Investigated by
Hoffmann-La Roche

Trials 22 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT01711775 Nov → Dec 2012 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01701739 Oct 2012 → Jan 2013 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01679639 Aug → Dec 2012 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01615354 Jul 2012 → Jan 2013 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01398267 Aug 2011 → Oct 2012 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01197911 Sep 2010 → Aug 2011 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01188304 Jul → Oct 2010 Hoffmann-La Roche Completed No outcome recorded
Phase 1 NCT01188317 Jun 2010 → Sep 2011 Hoffmann-La Roche Completed No outcome recorded
Phase 26 trials
Phase 2 NCT01729403 Dec 2012 → Sep 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT01680978 Oct 2012 → Sep 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT01043029 May 2010 → Jul 2012 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT00461006 Jun 2007 → Sep 2008 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT00461058 May → Dec 2007 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 2 NCT00388518 Nov 2006 → Mar 2008 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 38 trials
Phase 3 NCT01893242 Dec 2013 → Jan 2019 diabetic kidney disease Hoffmann-La Roche Withdrawn No outcome recorded
Phase 3 NCT01871428 Jun → Nov 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 3 NCT01871415 May → Aug 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 3 NCT01691989 Dec 2012 → Sep 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 3 NCT01715818 Dec 2012 → Nov 2013 diabetes mellitus, noninsulin-dependent, 2 Hoffmann-La Roche Completed No outcome recorded
Phase 3 NCT01691755 Nov 2012 → Sep 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 3 NCT01691846 Oct 2012 → Sep 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded
Phase 3 NCT01042769 Feb 2010 → Nov 2013 type 2 diabetes mellitus Hoffmann-La Roche Completed No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 24 sources stand behind the page.

FieldValueCited text
Known as aleglitazar ClinicalTrials.gov intervention name — accepted as the source's own label NCT01188304
21

NCT01680978

NCT01871428

NCT01871415

NCT00388518

NCT01729403

NCT00461006

NCT01691755

NCT01043029

NCT01615354

NCT01691846

NCT00461058

NCT01715818

NCT01398267

NCT01691989

NCT01042769

NCT01701739

NCT01188317

NCT01197911

NCT01711775

NCT01679639

NCT01893242

Known as R-1439 ChEMBL registry synonym — accepted as the source's own label CHEMBL519504
Known as RO0728804 “A Single-center, Non-randomized, Open-label Study to Assess the Pharmacokinetics of Aleglitazar (RO0728804) After Administration of Single and Multiple Oral Doses of 150 µg...” NCT01711775
Action Activate “Peroxisome proliferator-activated receptor gamma agonist” CHEMBL519504
2

“Peroxisome proliferator-activated receptor alpha agonist” CHEMBL519504

“the dual PPAR-alpha and PPAR-gamma agonist aleglitazar” PMID 19515415 Jun 2009

Modality Small molecule CHEMBL519504
Route Oral “Administered po daily” NCT00388518
Target PPARA “Peroxisome proliferator-activated receptor alpha agonist” CHEMBL519504
Target PPARG “Peroxisome proliferator-activated receptor gamma agonist” CHEMBL519504