Drugs / MODIMELANOTIDE
last change May 2014 re-read 3 minutes ago

MODIMELANOTIDE

also known as AP214 · ABT-719 · Modimelanotida · ZP-1480

Protein / enzyme biologic targets MC1R, MC3R via activation

Developed for
acute kidney injury · kidney disorder
Investigated by
Action Pharma A/S · AbbVie

Trials 5

20082009201020112012201320142015201620172018201920202021202220232024202520262027
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 2 NCT01897519 May 2013 → May 2014 — AbbVie Terminated No outcome recorded
Phase 2 NCT01777165 Feb 2013 → Mar 2014 acute kidney injury AbbVie Completed Missed primary
Phase 2 NCT01256372 Oct 2010 → Jun 2011 aortic aneurysm, kidney disorder Action Pharma A/S Completed No outcome recorded
Phase 2 NCT00903604 May 2009 → Jun 2010 aneurysm or dilatation of ascending aorta, cardiac valvular defect Action Pharma A/S Completed No outcome recorded
Phase 2 NCT00628264 Mar 2008 → Jun 2009 acute kidney injury, cardiac valvular defect, coronary artery intramyocardial course Action Pharma A/S Terminated No outcome recorded Stop: Enrollment

Evidence & citations 9 cited values

Every value below carries the sentence it was read from. 6 sources stand behind the page.

FieldValueCited text
Known as MODIMELANOTIDE ChEMBL registry synonym — accepted as the source's own label CHEMBL3545104 ↗
Known as ABT-719 ClinicalTrials.gov intervention name — accepted as the source's own label NCT01897519 ↗
1

NCT01777165 ↗

Known as AP214 ClinicalTrials.gov intervention name — accepted as the source's own label NCT00903604 ↗
2

NCT01256372 ↗

NCT00628264 ↗

Known as Modimelanotida ChEMBL registry synonym — accepted as the source's own label CHEMBL3545104 ↗
Known as ZP-1480 ChEMBL registry synonym — accepted as the source's own label CHEMBL3545104 ↗
Action Activate “Melanocortin receptor 3 agonist” CHEMBL3545104 ↗
1

“Melanocortin receptor 1 agonist” CHEMBL3545104 ↗

Modality Protein / enzyme biologic — CHEMBL3545104 ↗
Target MC1R “Melanocortin receptor 1 agonist” CHEMBL3545104 ↗
Target MC3R “Melanocortin receptor 3 agonist” CHEMBL3545104 ↗